| Japanese |
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| Title | 脊髄小脳変性症における99mTc-hexamethyl-propyleneamine oximeによるSingle Photon Emission Computed Tomography |
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| Subtitle | 原著 |
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| Authors | 小野志磨人*, 福永仁夫*, 森田浩一*, 大塚信昭*, 永井清久*, 王鋭*, 古川高子*, 村中明*, 柳元真一*, 友光達志*, 安田雄**, 寺尾章**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **神経内科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 3 |
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| Page | 243-253 |
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| Year/Month | 1988/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脊髄小脳変性症(SCD)患者11例に, 99mTc-HM-PAO SPECTを行い, 123I-IMP SPECT所見と比較, 検討した. また, 6例についてはTRHを負荷し, 集積の変化を検討した. SCDでは99mTc-HM-PAOの小脳/前頭葉の集積比は低下しており, しかも重症度に比例して, それは低下傾向を示した. 99mTc-HM-PAOと123I-IMP SPECTの小脳/前頭葉の集積比を比較すると, 11例中9例で123I-IMPの方が99mTc-HM-PAOよりも低値であった. TRH負荷により, 99mTc-HM-PAOの小脳/前頭葉の集積比の変化には, 一定傾向がみられなかった. さらに, 99mTc-HM-PAOと123I-IMPとでTRH負荷前後の小脳/前頭葉の集積比の反応のdiscrepancyがみられた. SCD患者では99mTc-HM-PAOと123I-IMPとの集積の違いやTRHに対する反応性の違いが認められ, 両者の集積機序を考える上で興味深い所見と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Spinocerebellar degeneration, 99mTc-hexamethyl-propyleneamine oxime (99mTc-HM-PAO), Single photon emission computed tomography (SPECT), TRH load. |
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| English |
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| Title | Single Photon Emission Computed Tomograph Using 99mTc-hexamethyl-propyleneamine Oxime in Spinocerebellar Degeneration |
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| Subtitle | Original Articles |
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| Authors | Shimato ONO*, Masao FUKUNAGA*, Koichi MORITA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Wang RUI*, Takako FURUKAWA*, Akira MURANAKA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Takeshi YASUDA**, Akira TERAO**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurology, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 3 |
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| Page | 243-253 |
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| Year/Month | 1988/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] 99mTc-HM-PAO SPECT was performed in 11 patients with spinocerebellar degeneration (SCD), and those findings were compared with 123I-IMP SPECT. In addition, changes of accumulation of 99mTc-HM-PAO after TRH loading were studied in 6 patients. In patients with SCD, cerebella/frontal lobes accumulation ratio decreased, and with increasing the severity of SCD its ratio decreased more remarkably. In comparative study of 99mTc-HM-PAO and 123I-IMP, it was shown that cerebella/frontal lobes accumulation ratio was lower in 123I-IMP than in 99mTc-HM-PAO in 9 of 11 patients. After TRH load, no definite change of cerebella/frontal lobes accumulation ratio was observed. Furthermore, discrepancy of accumulation ratio in 99mTc-HM-PAO and in 123I-IMP after TRH load was shown in 2 of 6 patients, Thus, it was shown that there existed the difference of accumulation and the discrepancy of response to TRH load of 99mTc-HM-PAO and 123I-IMP in patients with SCD. Therefore, these data will provide a useful information in evaluating the mechanisms of accumulation of 99mTc-HM-PAO and 123I-IMP. |
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| Practice | Clinical medicine |
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| Keywords | Spinocerebellar degeneration, 99mTc-hexamethyl-propyleneamine oxime (99mTc-HM-PAO), Single photon emission computed tomography (SPECT), TRH load. |
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