| Japanese |
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| Title | 核磁気共鳴を用いた心臓移植における拒絶心筋の23Na (ナトリウム) イメージング |
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| Subtitle | 原著 |
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| Authors | 西村恒彦*1, 佐田正晴*2, 笹木秀幹*2, 山田直明*1, 山田幸典*1, 由谷親夫*3, 雨宮浩*2, 藤田毅*, 阿久津哲造*, 曲直部寿夫* |
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| Organization | *国立循環器病センター, *1放射線診療部, *2実験治療部, *3病理部 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 12 |
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| Page | 1741-1748 |
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| Year/Month | 1987/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心臓移植後, 拒絶心筋の23Na(ナトリウム)イメージングに初めて成功したので報告する. 雑種成犬12頭を用い(ドナー6頭, レシピエント6頭), 胸腔内異所性心移植モデルを作成, 拒絶反応を生じた5〜6日後に, ドナー心を摘出, NMR-CT装置(1.5 Tesla)を用い, 23Naイメージングを行った. 同時に, 1H(プロトン)イメージングを行いT1, T2緩和時間を算出した. これらの成績は, 同割面における病理組織所見(mild, moderate, severe rejection)と対比した. 拒絶反応スコアとT1, T2緩和時間, 23Na信号強度比はそれぞれ0.79, 0.70, 0.80と良好な相関を示した. また, 23Naイメージングでは, moderateないしsevere rejectionで拒絶心筋は明瞭に描出され, これは心筋細胞壊死に基づく細胞内外の23Naの増加を反映していると考えられた. 23Naイメージングは, 心移植において拒絶心筋の性状評価が行える可能性が示されたが臨床応用はなお現状では困難である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Sodium MRI, Heterotopic heart transplantation, Cardiac rejection. |
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| English |
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| Title | Sodium Nuclear Magnetic Resonance Imaging of Acute Cardiac Rejection in Heterotopic Heart Transplantation |
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| Subtitle | - Original Articles - |
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| Authors | Tsunehiko NISHIMURA, Masaharu SADA, Hidemiki SASAKI, Naoaki YAMADA, Yukinori YAMADA, Chikao YUTANI, Hiroshi AMEMIYA, Tsuyoshi FUJITA, Tetsuzo AKUTSU, Hisao MANABE |
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| Authors(kana) | |
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| Organization | Department of Radiology, Surgical Research and Pathology, National Cardiovascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 12 |
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| Page | 1741-1748 |
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| Year/Month | 1987/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Nuclear magnetic resonance (NMR) imagings have been applied to the observation of tissue sodium-23 in myocardium undergoing cardiac rejection. Six canine donor hearts were hetero-topically transplanted in the recipient's chest cavity. The dogs were then killed and sodium-23 image of the excised donor hearts were obtained using a high field MNR imaging system (1.5 Tesla, Magnetom). Proton NMR imaging was also performed and T1, T2 relaxation times were calculated. Subsequently, these data were correlated with pathologic findings such as mild, moderate and severe rejection. The correlation coefficients between rejection score, and T1, T2 times and sodium NMR signal intensity were 0.79, 0.70 and 0.80, respectively. The moderate or severe rejected myocardium were clearly visible as areas of increased sodium NMR signal. These data suggested that increase of sodium may be mainly caused by the myocardial cellular necrosis. Sodium NMR will allow us to evaluate the location and extent of rejected myocardium undergoing heart transplantation. |
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| Practice | Clinical medicine |
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| Keywords | Sodium MRI, Heterotopic heart transplantation, Cardiac rejection. |
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