| Japanese |
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| Title | Gd-DTPAによるMRI腎ファンクショナルイメージ作成の試み |
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| Subtitle | 研究速報 |
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| Authors | 池平博夫*, 青木芳朗**, 長原陽子***, 山根昭子*, 福田信男*, 松本徹*, 遠藤真広*, 飯沼武*, 福田寛*, 舘野之男* |
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| Organization | *放射線医学総合研究所臨床研究部, **病院部, ***旭メディカル(株) |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 11 |
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| Page | 1683-1687 |
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| Year/Month | 1987/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」 われわれはこれまでに, MRI造影剤であるGd-DTPA (gadolinium-diethylene triamin pentaacetic acid) がGFR (glomerular filtration ratio) 物質であることに着目して, MRIによる腎動態機能検査法を考案し, 動物実験によりその基礎的検討と有効性の評価を行い報告してきた. ところが今回シェーリング社よりGd-DTPAの提供を受ける機会を得たので, 6名の腎機能正常ボランティアを対象としてヒトの正常腎機能評価の目的でわれわれがすでに報告した手法を応用して, その有効性の確認を行った. さらに局所腎機能評価のために, 腎ファンクショナルイメージの作成を試み, 腎動態機能の可視化と局所腎機能評価に有効であるという示唆が得られたので報告する. |
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| Practice | 臨床医学：一般 |
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| Keywords | Gd-DTPA, MRI, Renal function, Functional image. |
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| English |
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| Title | Experimental Production of MRI Renal Functional Image Using Gd-DTPA |
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| Authors | Hiroo IKEHIRA*, Yoshiro AOKI**, Yoko NAGAHARA***, Teruko YAMANE*, Nobuo FUKUDA*, Toru MATUMOTO*, Masahiro ENDO*, Takeshi IINUMA*, Hiroshi FUKUDA*, Yukio TATENO* |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, **Division of Hospital, National Institute of Radiological Sciences, ***Asahimedical Co. Ltd. |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 11 |
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| Page | 1683-1687 |
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| Year/Month | 1987/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We already developed and reported the MRI renal kinetic function study method using Gd-DTPA as a magnetopharmaceutical for the GFR substance. These trials were evaluated as a experimental studies. But these days we could get Gd-DTPA supply from Schering Co. Ltd. , so we applied this method to the human being for the purpose of normal human renal kinetic function analysis. Normal six volunteers' examinations were done, six volunteers were 25 to 61 years average 45 years old females and 18 years old male. In this paper we evaluated normal human renal kinetic function to get GFR value, tubular urine flow value, tubular back diffusion value and tubular volume parameters and also we had tried to make the GFR functional image. We got these normal values as follows, GFR value was 79.2+-16.1 ml/min, tubular urin flow value was 68.7+-21.5 ml/min, tubular back diffusion value was 1.98+-6.61 μmol/min and tubular volume value was 0.148+-0.719 ml, but last two values, tubular back diffusion value and tubular volume value were almost 0 values in the cases of normal volunteers. Intra renal local blood flow (GFR) pattern was visualized with MRI GFR functional image. This GFR image indicated the irregular pattern of intra renal local blood flow, even if in the case of normal function kidney. |
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| Practice | Clinical medicine |
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| Keywords | Gd-DTPA, MRI, Renal function, Functional image. |
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