Japanese
Title123I-iodoamphetamineを用いた経直腸門脈シンチグラフィによるPortosystemic Shuntの診断
Subtitle原著
Authors柏木徹*, 東正祥*, 井川宣*, 竹原徹郎*, 松田裕之*, 吉岡博昭*, 満谷夏樹*, 小泉岳夫*, 木村和文**
Authors(kana)
Organization*大阪厚生年金病院内科, **大阪大学医学部中央放射線部
Journal核医学
Volume24
Number11
Page1663-1670
Year/Month1987/11
Article原著
Publisher日本核医学会
Abstract「要旨」非肝疾患および各種肝疾患患者65例を対象に123I-iodoamphetamine (IMP) 3 mCi直腸内投与による経直腸門脈シンチグラフィを行い, portosystemic shunt indexを測定し, 門脈循環動態を検討した. 全例でIMP投与後5-10分で肝あるいは肺のイメージが描出され, 次第に明瞭化した. 非肝疾患例では肝のみ, 肝疾患とくに肝硬変例では肝と肺あるいは肺のみが描出された. 肝および肺でのtime-activity curveはIMP投与直後より急峻に上昇し, 60分後においてもplateauに達せず, IMPの直腸からの吸収が速やかで肝, 肺からのwashoutが緩徐であることを示した. portosystemic shunt indexは, 肺のcount数を肝と肺のcount数で除して算出した. このshunt indexはIMP投与後30-60分の間ほとんど変動せず, 肝硬変では代償期56.9%, 非代償期92.3%で非肝疾患0%, 急性肝炎7.2%, 慢性肝炎15.1%に比し有意に上昇していた. したがって, IMPによる経直腸門脈シンチグラフィは門脈循環異常の優れた診断法になり得ると考えられた.
Practice臨床医学：一般
Keywords123I-iodoamphetamine, Transrectal portal scintigraphy, Portal circulation, Portosystemic shunt, Liver cirrhosis.
English
TitleEvaluation of Portosystemic Shunt by Transrectal Portal Scintigraphy with I-123 Iodoamphetamine
SubtitleOriginal Articles
AuthorsToru KASHIWAGI*, Masayoshi AZUMA*, Takashi IKAWA*, Tetsuo TAKEHARA*, Hiroyuki MATSUDA*, Hiroaki YOSHIOKA*, Natsuki MITSUTANI*, Takeo KOIZUMI*, Kazufumi KIMURA**
Authors(kana)
Organization*Department of Internal Medicine, Osaka Kosei-Nenkin Hospital, **Department of Radiology and Nuclear Medicine, Osaka University Hospital
JournalThe Japanese Journal of nuclear medicine
Volume24
Number11
Page1663-1670
Year/Month1987/11
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Portosystemic shunt was evaluated by rectal administration of I-123 iodoamphetamine (IMP) in 65 patients without and with various liver diseases. A dose of 3 mCi of IMP was given into the rectum through a thin catheter. Images of the chest and abdomen were obtained with a large field of view camera interfaced to a computer up to 60 min. The portosystemic shunt index was calculated using the following equation: Shunt Index = Counts of Lung / Counts of (Liver + Lung) × 100 (%) In all patients, the liver and/or lung were visualized on the 5-10 min image and became clear with time. Time-activity curves over liver and lung rose promptly after IMP administration and were on the rise 60 min later. These results suggest that IMP is rapidly absorbed from the rectum and taken up by the liver and lung at a high rate and retained in these organs. In 60 out of 65 patients, shunt indexes were almost constant between 30 and 60 min after IMP administration. Shunt indexes were 0% in patients without liver diseases, 7.2% in acute hepatitis, 15.1% in chronic hepatitis, 56.9% in compensated liver cirrhosis and 92.3% in decompensated liver cirrhosis. Shunt indexes were significantly higher in liver cirrhosis, especially decompensated stage. Therefore, transrectal portal scintigraphy with IMP is considered to be useful as the noninvasive and quantitative evaluation of portosystemic shunt in patients with liver diseases.
PracticeClinical medicine
Keywords123I-iodoamphetamine, Transrectal portal scintigraphy, Portal circulation, Portosystemic shunt, Liver cirrhosis.

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