Japanese
Titleてんかん患者におけるN-isopropyl-P-[123I]-iodoamphetamineによるSingle Photon Emission Computed Tomography (SPECT)
Subtitle原著
Authors小野志磨人*, 福永仁夫*, 大塚信昭*, 永井清久*, 光森通英*, 村中明*, 古川高子*, 柳元真一*, 友光達志*, 安田雄**, 寺尾章**, 曽根照喜***, 森田陸司*
Authors(kana)
Organization*川崎医科大学核医学科, **神経内科, ***京都大学医学部放射線核医学科
Journal核医学
Volume24
Number11
Page1641-1652
Year/Month1987/11
Article原著
Publisher日本核医学会
Abstract「要旨」てんかん患者のてんかん焦点の検出や脳循環を知るために, 123I-IMPによるSingle Photon Emission Computed Tomography (SPECT) をてんかん患者38例 (症候性14例, 真性24例, うち1例は発作時および非発作時の2回に検査を施行) に施行し, X線CTおよび脳波の所見と比較検討した. 症候性てんかんでは14例中13例に, 真性てんかんの非発作時では23例中16例に, その発作中では2例全例に, 123I-IMPの集積異常が観察された. 一方, X線CTによる真性てんかんの脳局所異常の検出能 (24例中2例) は123I-IMP SPECTに比して明らかに劣っていた. さらに脳波所見とを比較すると, 脳波上異常のみられない10例の非発作時の真性てんかん患者のうち, 6例に123I-IMPの集積異常が観察された. ただし, てんかん焦点への123I-IMPの集積は増加するもの, 低下するものと一定ではなく, さらに脳波上の発作波の部位と一致しない部位に集積低下を示す症例もみられた. 123I-IMPのてんかん焦点への集積機序については未解決な問題が存在するが, 123I-IMP SPECTは, てんかんにおける脳局所異常の検出に有用であることが示された.
Practice臨床医学：一般
KeywordsN-isopropyl-p-[123I]-iodoamphetamine, Epilepsy, Single photon emission computed tomography (SPECT) .
English
TitleSingle Photon Emission Computed Tomography (SPECT) Using N-isopropyl-p-[123I]-iodoamphetamine in Epilepsy
SubtitleOriginal Articles
AuthorsShimato ONO*, Masao FUKUNAGA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Michihide MITSUMORI*, Akira MURANAKA*, Takako FURUKAWA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Takeshi YASUDA**, Akira TERAO**, Teruki SONE***, Rikushi MORITA*
Authors(kana)
Organization*Department of Nuclear Medicine, **Neurology, Kawasaki Medical School, ***Department of Radiology and Nuclear Medicine, Kyoto University
JournalThe Japanese Journal of nuclear medicine
Volume24
Number11
Page1641-1652
Year/Month1987/11
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] In order to delineate a seizure focus and to clarify the cerebral blood flow in epilepsy, single photon emission computed tomography (SPECT) using N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) was performed on 38 patients (14 symptomatic and 24 idiopathic epilepsy including one patient who was studied on both ictal and interictal phase) , and the findings of 123I-IMP SPECT were compared with those of X-ray computed tomography (X-CT) and electroencephalogram (EEG) . Abnormality of accumulation of 123I-IMP was observed in 13 out of the 14 symptomatic, 16 out of the 23 interictal idiopathic and all of the 2 ictal idiopathic epileptic patients. On the other hand, in idiopathic epilepsy the detectability (2/24) of focal abnormality in the brain by X-CT was found to be lower than that of 123I-IMP SPECT. In 6 out of the 10 interictal idiopathic epileptic patients, showing normal EEG, the abnormality of accumulation of the radionuclide was observed on 123I-IMP SPECT. Among these 6 idiopathic epileptic patients, however, the pattern of the accumulation of the radionuclide was variable; some patients showed the increased accumulation in the seizure focus, others did the decreased perfusion. Furthermore, some cases showed the decreased perfusion in the different areas from the lesions of epileptic discharge on EEG. Although the mechanism of accumulation of 123I-IMP in the seizure foci is not completely clear, 123I-IMP SPECT was thought to be useful in the detection of focal abnormality in brain in epilepsy.
PracticeClinical medicine
KeywordsN-isopropyl-p-[123I]-iodoamphetamine, Epilepsy, Single photon emission computed tomography (SPECT) .

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