| Japanese |
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| Title | 99mTc-hexamethylpropylene-amine oximeを用いた脳腫瘍および脳動静脈奇形患者の脳血流SPECT - CT, 133Xe, 123I-IMPとの比較 - |
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| Subtitle | 原著 |
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| Authors | 星博昭*, 陣之内正史*, 渡辺克司*, 大西隆*, 宇和田収*, 中野真一**, 木下和夫** |
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| Authors(kana) | |
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| Organization | *宮崎医科大学放射線科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 11 |
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| Page | 1617-1623 |
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| Year/Month | 1987/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳腫瘍患者20例に対して99mTc-hexamethylpropylene-amine oxime (HM-PAO) によるSPECTを施行し, CT, 123I-IMP SPECT, 133Xe吸入法による局所脳血流像 (LCBF) と比較した. 装置は, リング型ECT装置SET-020 (島津製) で, データ収集, 処理はミニコンピュータシステムECLIPSE S-120 (日本データジェネラル) を用いた. HM-PAO SPECTは, 10〜20 mCiを静注し, 30分後より600 kカウントでデータ収集した, 得られたHM-PAOのSPECT像, および123I-IMP, 133XeのLCBF像でみられる脳血流障害範囲を, X線CT上の腫瘍および周辺浮腫の範囲と比較した. 次に, 腫瘍部分のRI取り込みの指標として, T/N比 (腫瘍および対側の皮質に相当する部分のカウント数の比) を算出した. 原発性脳腫瘍, 脳転移, 脳動静脈奇形 (AVM) の大部分で, CT上の腫瘍または腫瘍と周辺浮腫まで含めた範囲に, HM-PAO, IMP, 133Xeの両者で血流欠損を認めた. 133Xeで腫瘍の部分の血流増加を示したものは6例あり, HM-PAOではこのうち3例 (髄膜腫2例, high grade astrocytoma 1例) で高集積, IMPでは2例 (髄膜腫とhigh grade astrocytoma) で高集積であった. いずれも血流障害の範囲は周辺浮腫まで及んでいた. 腫瘍部分のHM-PAOの取り込みの程度を示すT/N比は, 39〜137%と腫瘍の種類により大きな差がみられた. 133XeのLCBFやIMPで求めたT/N比と比較すると, それぞれ, r=0.50, r=0.63の相関がみられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain tumor, Arterio-venous malformation, Tc-99m hexamethylpropylene-amine oxime, N-isopropyl-p[I-123]iodoamphetamine, Single photon emission computed tomography. |
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| English |
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| Title | Cerebral Blood Flow Imaging in Patients with Brain Tumor and Arterio-venous Malformation Using Tc-99m Hexamethylpropylene-amine Oxime - A Comparison with Xe-133 and IMP - |
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| Subtitle | Original Articles |
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| Authors | Hiroaki HOSHI*, Seishi JINNOUCHI*, Katsushi WATANABE*, Takashi ONISHI*, Osamu UWADA*, Shinichi NAKANO**, Kazuo KINOSHITA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurosurgery, Miyazaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 11 |
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| Page | 1617-1623 |
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| Year/Month | 1987/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Single photon emission computed tomography of the brain using a ring type gamma-camera (SET-020, Shimadzu Co. ) , following intravenous injection of Tc-99m hexamethylpropylene-amine oxime (HM-PAO) was studied in 20 patients with brain tumors (meningioma; 4, astrocytoma; 6, pituitary tumor; 1, germinoma; 1, metastases; 5, arterio-venous malformation (AVM) ; 3) . Ratios of tumor activities to those of contralateral sides (T/N ratios) are calculated, and they were compared to those obtained by Xe-133 and IMP. In 17 patients, HM-PAO and IMP activities are low in the lesion of tumor and edema regardless of tumor type. High activities of HM-PAO are observed in 2 patients with meningioma and in 1 patient with high grade astrocytoma, and high activity of IMP was observed in 1 patient with meningioma and in 1 patient with high grade astrocytoma. Correlation coefficients of T/N ratios between Xe-133 and HM-PAO, IMP and HM-PAO were 0.50 and 0.63, respectively. T/N ratios varied from 39 to 137, and they may reflect tumor blood flows. In conclusion, HM-PAO SPECT may be a useful radiopharmaceutical for the evaluation of cerebral blood flow in patients with brain tumor and AVM. |
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| Practice | Clinical medicine |
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| Keywords | Brain tumor, Arterio-venous malformation, Tc-99m hexamethylpropylene-amine oxime, N-isopropyl-p[I-123]iodoamphetamine, Single photon emission computed tomography. |
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