Japanese
Title虚血心筋におけるフルオロデオキシグルコースの集積 (第2報) - 梗塞心筋部の血流および壁運動との比較検討 -
Subtitle原著
Authors玉木長良*, 米倉義晴*, 千田道雄*, 佐治英郎*, 山本和高*, 西澤貞彦*, 柴田登志也*, 不藤哲郎**, 橋本哲男**, 神原啓文**, 河合忠一**, 小西裕***, 間賀田泰寛****, 伴敏彦***, 小西淳二*
Authors(kana)
Organization*京都大学医学部放射線核医学科, **第三内科, ***心臓血管外科, ****京都大学薬学部
Journal核医学
Volume24
Number10
Page1529-1538
Year/Month1987/10
Article原著
Publisher日本核医学会
Abstract「要旨」 心筋梗塞33例に13N-アンモニアと18FDGを用いたポジトロンCTを施行し, 梗塞巣のviabilityの評価を試みた. 発症3か月以内の梗塞 (RMI) 例では3か月以降の古い梗塞 (OMI) 例に比べより高頻度に梗塞巣への18FDGの集積がみられた (P<0.001) . 梗塞巣の13N-アンモニアの分布と対比すると, 血流低下の軽度な領域ほど18FDGの集積が増加していた (P<0.01) . また梗塞責任冠動脈が完全閉塞していない領域で18FDGの集積が高く(P<0.05) , 梗塞巣のviabilityには血流保持が重要であることが示唆された. RMI例では運動負荷で血流低下を示した領域で18FDGの集積が増加していた (P<<0.02) . 一方左室造影との対比では, 壁運動異常の軽度な梗塞領域ほど18FDGの集積が増加していた (P<0.02) . ただdyskinesisを伴う領域の31%にも18FDGの著明な集積がみられた. ポジトロンCTによる18FDGの集積は, 他の臨床指標とよく相関し, エネルギー代謝の面からの心筋病態の解明に役立つと考えられた.
Practice臨床医学:一般
KeywordsPositron emission tomography, 18F-fluorodeoxyglucose, 13N-ammonia, Myocardial perfusion, Myocardial infarction
English
TitleAccumulation of Fluorodeoxyglucose in Ischemic Myocardium - II. Comparison with Myocardial Perfusion and Regional Wall Motion -
SubtitleOriginal Articles
AuthorsNagara TAMAKI*, Yoshiharu YONEKURA*, Michio SENDA*, Hideo SAJI*, Kazutaka YAMAMOTO*, Sadahiko NISHIZAWA*, Toshiya SHIBATA*, Tetsuro FUDO**, Tetsuo HASHIMOTO**, Hirofumi KAMBARA**, Chuichi KAWAI**, Yutaka KONISHI***, Yasuhiro MAGATA†, Toshihiko BAN***, Junji KONISHI*
Authors(kana)
Organization*Department of Radiology and Nuclear Medicine, **Third Division,Department of Internal Medicine, ***Department of Cardiovascular Surgery, Kvoto University School of Medicine, †Kyoto University Department of Radiopharmaceutical Science
JournalThe Japanese Journal of nuclear medicine
Volume24
Number10
Page1529-1538
Year/Month1987/10
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Positron emission tomography (PET) using 13N-ammonia and 18F-fiuorodeoxyglucose (18FDG) was performed in 33 patients with myocardial infarction to assess myocardial viability of ECG determined infarct segments. 18FDG uptake in infarct segments was compared with myocardial perfusion by 13N-ammonia, coronary stenosis and regional wall motion by contrast ventriculography. Increased 18FDG uptake was more often seen in patients with recent myocardial infarction (RMI) than those with old infarction (p<0.001) . 18FDG uptake was more increased in those with mild hypoperfusion (P<0.01) and those supplied by recanalized coronary arteries (P<0.05) , suggesting that residual flow to the infarct zone may be crucial to maintain myocardial viability. In RMI, an increase in 18FDG uptake was more often observed in infarct segments with stress induced hypoperfusion (p<0.02) . Furthermore, 18FDG uptake was more increased in those with milder wall motion abnormalities (p<0.02) . However, 18FDG uptake was also observed in 31% of those with dyskinesis. These data suggest that an increase in 18FDG uptake in infarct segments was observed in area with less severe hypoperfusion and milder regional wall motion abnormalities, indicating 18FDG uptake as a useful predictor of myocardial viability in infarct segments.
PracticeClinical medicine
KeywordsPositron emission tomography, 18F-fluorodeoxyglucose, 13N-ammonia, Myocardial perfusion, Myocardial infarction

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