| Japanese |
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| Title | Tc-99m-PMT肝胆道シンチグラフィのdeconvolution analysisによる検討 |
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| Subtitle | 原著 |
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| Authors | 権重禄*, 中川毅*, 前田寿登*, 中村和義*, 田代敬彦*, 佐久間肇*, 加藤憲幸*, 松岡洋一郎*, 平野忠則*, 山口信夫* |
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| Organization | *三重大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 9 |
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| Page | 1303-1311 |
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| Year/Month | 1987/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」各種肝疾患患者37例および正常対照例26例を対象としてdeconvolution analysisによりTc-99m-PMT肝胆道シンチグラフィのデータを処理し, 肝の伝達関数を求めて診断に用いた. 伝達関数は肝に直接RIをbolus注入した時に得られる時間放射能曲線に相当し, 肝血流の因子を分離した肝固有の排泄機能を通過時間の分布として表示するものである. 対照例26例で求めた右葉の伝達関数の最小, 平均, 最大通過時間はそれぞれ6.8±1.1分, 14.9±2.3分, 32.8±4.9分(mean±SD)に分布し, 急性肝炎3例, 慢性肝炎20例, 肝硬変14例では平均, 最大通過時間に有意の延長を認めた. これら症例のうち30例において経時的採血による血中濃度曲線から求めた有効肝血流量と平均通過時間および最大通過時間との間には有意の逆相関(それぞれr=-0.51, r=-0.70)が認められた. 各画素ごとに求めた伝達関数から算出した最小, 平均, 最大通過時間の分布をカラー表示して作成したfunctional imageは肝内局所の通過時間を定量的に示し, 診断に有益であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hepatobiliary scintigraphy, Deconvolution analysis, Transfer function, Transit time, Functional image. |
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| English |
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| Title | Application of Deconvolution Analysis to Tc-99m-PMT Hepatobiliary Scintigraphy |
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| Subtitle | Original Articles |
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| Authors | Jyuroku GON, Tsuyoshi NAKAGAWA, Hisato MAEDA, Kazuyoshi NAKAMURA, Takahiko TASHIRO, Hajime SAKUMA, Noriyuki KATO, Yoichiro MATSUOKA, Tadanori HIRANO, Nobuo YAMAGUCHI |
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| Organization | Department of Radiology, Mie University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 9 |
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| Page | 1303-1311 |
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| Year/Month | 1987/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Deconvolution analysis was applied to hepatobiliary imaging with 99mTc-N-Pyridoxyl-5-Methyltryptophan (PMT) to obtain the transfer function (TF) which corresponds to the impulse response function of the liver following direct bolus injection of the tracer into the main hepatic vasculature. Consequently TF represents the spectrum of transit time (TT) separated from the factor of blood flow. Minimum (min), mean and maximum (max) TT measured in right lobe of normal control group averaged 6.8+-1.17 (S.D.) min., 14.9+-2.3 min. and 32.9+-4.9min., respectively. In each of the groups of 3 cases of acute hepatitis, 20 cases of chronic hepatitis and 14 cases of liver cirrhosis, mean TT and max TT were significantly prolonged. In cases of normal control, chronic hepatitis and liver cirrhosis there was a significant inverse correlation between mean TT and effective hepatic blood flow (EHBF) estimated from blood clearance (r=-0.515, p<0.01). In patients with acute hepatitis there was an increase in EHBF against an increase in mean TT, so that the correlation was far from that in other groups. In patients with liver cirrhosis TF tends to show fluctuating pattern indicating interrupted bile flow with mixing. The correlation between TT and EHBF, as well as the shape of the TF, were very interesting in evaluating the pathophysiology of the liver in patients with various liver diseases. Functional images of min TT, mean TT and max TT, which displayed respective TT for each element of the matrix in a color scale, were very useful for quantitative evaluation of regional excretory function. |
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| Practice | Clinical medicine |
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| Keywords | Hepatobiliary scintigraphy, Deconvolution analysis, Transfer function, Transit time, Functional image. |
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