| Japanese |
|---|
| Title | 甲状腺組織への201Tlの集積機序の解明 - 201Tl-chlorideシンチグラフィのdynamic studyによる甲状腺腫瘍の質的診断の有用性 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 岸田敏博* |
|---|
| Authors(kana) | |
|---|
| Organization | *自治医科大学消化器・一般外科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 24 |
|---|
| Number | 7 |
|---|
| Page | 991-1004 |
|---|
| Year/Month | 1987/7 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」甲状腺疾患91例に201Tl-chlorideシンチグラフィを施行し, 腫瘍部と正常部の集積像をコンピュータ画像処理しtime-activity curveを作製した. 手術によりえられた甲状腺腫瘍および正常甲状腺組織のNa+, K+-ATPase活性を測定し, その酵素活性と201Tlの集積の関係を腫瘍の病理組織像について検討した. さらに, 甲状腺手術中に腫瘍部と正常部の甲状腺組織血流量を測定し, 201Tlの集積とtime-activity curveについても検討し, 以下の結論をえた. 1)腫瘍部と正常部における酵素活性と201Tlの初期集積の間には正の相関を認め, 201Tlの甲状腺への取り込みはNa+, K+-ATPaseに依存していると考えられた. 2)甲状腺腫瘍の組織血流量と201Tlの集積の間にも正の相関を認め, 201Tlの集積は甲状腺の組織血流にも依存していると考えられた. 3)time-activity curveを組織像についてみると, washout良好で組織像が濾胞型構造を示す腫瘍と, washout不良で乳頭型構造を示す腫瘍の2つに大別された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Thallium-201 scintigraphy, Na+, K+-ATPase, Thyroid blood flow. |
|---|
| English |
|---|
| Title | Mechanisms of Thallium-201 Accumulation to Thyroid Gland - Clinical Usefulness of Dynamic Study in Thallium-201 Chloride Scintigraphy for Differential Diagnosis of Thyroid Nodules - |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Toshihiro KISHIDA |
|---|
| Authors(kana) | |
|---|
| Organization | Department of General Surgery, Jichi Medical School |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 24 |
|---|
| Number | 7 |
|---|
| Page | 991-1004 |
|---|
| Year/Month | 1987/7 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]In this study 91 patients with goiter were scintigraphed for the duration of 84 minutes after intravenous administration of thallium-201 by digital γ camera lined to computer data system. Regions of interest (ROIs) were assigned for thyroid tumor, normal thyroid and back ground, and time-activity curves (TACs) were generated from these ROIs. Na+, K+-ATPase activity of microsome fraction from thyroid tumor and the normal thyroid glands was determined. The first 15 minutes accumulation of each ROI was determined as the early accumulation of thallium-201 for tumor and the normal thyroid glands. Papillary and follicular carcinomas, showing the high accumulation of thallium-201, had high activity of Na-, K+-ATPase. Microfollicular adenomas had high activity of Na+, K+-ATPase and demonstrated intense accumulation of thallium-201. However, colloid adenoma had a similar level of Na+, K+-ATPase activity to that of the normal thyroid glands and did not demonstrate radionuclide accumulation. Consequently, radionuclide accumulation in thallium-201 thyroid scintigraphy was closely correlated to Na+, K+-ATPase activity of thyroid tumor. Thyroid blood flow was measured by hydrogen gas clearance method. Thyroid blood flow of papillary carcinoma was smaller, as compared with normal thyroid blood flow. TAC of papillary carcinoma showed flattening. Thallium-201 accumulation in early image was also found to correspond to thyroid blood flow. From this study we can conclude that mechanisms of thallium-201 accumulation in a thyroid tumor depends on Na+, K+-ATPase activity and thyroid blood flow. Washout of TAC in thallium-201 scintigraphy appears dependent on blood flow of a thyroid nodule. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Thallium-201 scintigraphy, Na+, K+-ATPase, Thyroid blood flow. |
|---|