| Japanese |
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| Title | カプトプリル投与中の分腎機能変化 - 腎血管性高血圧における診断的意義 - |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 高山輝彦*, 中嶋憲一*, 利波紀久*, 久田欣一*, 安原修一郎**, 宮森勇**, 竹田亮祐** |
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| Organization | *金沢大学医学部核医学教室, **第二内科学教室 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 7 |
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| Page | 975-982 |
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| Year/Month | 1987/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」降圧剤の一種であるアンジオテンシン変換酵素阻害剤のカプトプリルを用い, 腎血管性高血圧を含む高血圧患者を対象に一定期間持続投与して, GFR, ERPFの面より分腎機能変化を観察し, 腎血管性高血圧診断におけるカプトプリル薬剤負荷腎核医学検査の有用性を検討した. 腎血管性高血圧8例では, 持続投与中動脈狭窄側の分腎機能のうち, ERPFは僅かな増加を示したものの有意な変化を示さなかったのに対し, GFRは特異的低下を示した. 一方本態性高血圧を含む非腎血管性高血圧13例では, 持続投与中ERPFは同様に僅かな増加を示したものの, GFRの変動は見られなかった. 以上, カプトプリル薬剤負荷腎核医学検査は, 腎血管性高血圧の診断成績向上に有用であり, その際には131I-hippuranによるERPF検査よりも, 99mTc-DTPAによるGFR検査による評価が適当と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Glomerular filtration rate, Effective renal plasma flow, Renovascular hypertension, Essential hypertension, Captopril. |
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| English |
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| Title | Alteration of Split Renal Function during Captopril Treatment : Diagnostic Significance in Renovascular Hypertension |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO*, Teruhiko TAKAYAMA*, Kenichi NAKAJIMA*, Norihisa TONAMI*, Kinichi HISADA*, Shuichirou YASUHARA**, Isamu MIYAMORI**, Ryoyu TAKEDA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Second Department of Internal Medicine, Kanazawa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 7 |
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| Page | 975-982 |
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| Year/Month | 1987/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Two different methods to evaluate the alteration of split renal function following continued Captopril treatment were studied in a total of 21 patients with hypertension. Eight patients with renovascular hypertension (five with unilateral renal artery stenosis and three with bilateral renal artery stenosis), three patients with diabetic nephropathy, one patient with primary aldosteronism, and nine patients with essential hypertension were included. The studies were performed the day prior to receiving Captopril (baseline), and 6th or 7th day following continued Captopril treatment (37.5 mg or 75 mg/day). Split effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) after injections of I-131 hippuran and Tc-99m DTPA were measured using kidney counting corrected for depth and dose, described by Schlegel and Gates. In the patients with renovascular hypertension, split GFR in the stenotic kidney was significantly decreased 6th or 7th day following continued Captopril treatment compared to a baseline value. And split ERPF in the stenotic kidney was slightly increased although significant increase of split ERPF was not shown. In the patients with diabetic nephropathy, primary aldosteronism or essential hypertension, on the other hand, split GFR was not changed and split ERPF was slightly increased. These findings suggest that the Captopril induced alterations of split renal function may be of importance for the diagnosis of renovascular hypertension. For this purpose, split GFR determination is more useful than split ERPF determination. |
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| Practice | Clinical medicine |
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| Keywords | Glomerular filtration rate, Effective renal plasma flow, Renovascular hypertension, Essential hypertension, Captopril. |
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