Japanese
Title67Ga DFO-DAS-Fibrinogenによる血栓シンチグラフィ - 第2報 67Ga DFO-DAS-Fibrinogenの臨床応用 -
Subtitle原著
Authors川崎幸子*
Authors(kana)
Organization*東京女子医科大学放射線医学教室
Journal核医学
Volume24
Number6
Page827-836
Year/Month1987/6
Article原著
Publisher日本核医学会
Abstract「要旨」67Ga DFO-DAS-Fibrinogenの血栓描出用放射性医薬品としての有用性をin vivo実験にて検討した(第1報). 今回は67Ga DFO-DAS-Fibrinogenの臨床応用を試み, 血液凝固能, 血栓発症後の期間および抗血栓剤投与の影響を検討した. 対象はX線CTおよび他検査にて血栓の存在が確認されている48例であった. 対象疾患は解離性大動脈瘤を含む大動脈瘤20例, 人工血管置換術後11例, 心疾患に伴う心腔内血栓9例, 閉塞性動脈硬化症と脳梗塞の各1例, 静脈血栓症の6例であった. シンチグラムの結果は動脈血栓の42例中23例, 静脈血栓の6例中3例が陽性描画された. 疾患別では大動脈瘤が高い描出率を示し, 左房内血栓の描出率は低かった. 67Ga DFO-DAS-Fibrinogenの血栓への集積と血栓の発症期間, 抗血栓剤投与の有無, 凝固因子と対比したが, いずれも明らかに影響する因子は見いだせなかった. 67Ga DFO-DAS-Fibrinogenは血栓をイメージングするのに有用であり, 血栓の活性動態を示唆する代謝性薬剤であると思われた.
Practice臨床医学：一般
KeywordsGa-67 DFO-DAS-Fibrinogen, Thrombus, Clinical evaluation.
English
TitleThrombus Scintigraphy with Ga-67 DFO-DAS-Fibrinogen - Report II Clinical Applications of Ga-67 DFO-DAS-Fibrinogen -
SubtitleOriginal Articles
AuthorsYukiko KAWASAKI
Authors(kana)
OrganizationDepartment of Radiology, Tokyo Women's Medical College
JournalThe Japanese Journal of nuclear medicine
Volume24
Number6
Page827-836
Year/Month1987/6
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]In our previous in vivo study 67Ga DFO-DAS-Fibrinogen was assessed for its usefulness as a radiopharmaceutical for the detection of thrombi in experimental animals (Report 1). The present study was undertaken to appraise the diagnostic value of 67Ga DFO-DAS-Fibrinogen in human disease, especially in relation to blood coagulability as well as to thrombolytic drug regimen being given, in an effort to investigate its clinical applicability. Involved in this study were 48 patients with thrombosis proven by X-ray CT and other examinations. Of these 48, 42 had arterial thrombosis (20 with aortic aneurysm including the dissecting form, 11 in postoperative condition following vascular surgery with a prosthesis, 9 with intracardiac thrombosis accompanying heart disease, and 1 each with occlusive arteriosclerosis and cerebral infarction) and 6 had venous thrombosis. The 67Ga DFO-DAS-Fibrinogen test proved to be positive in 55% of arterial thrombi and in 50% of venous thrombi. It is interesting to note that as high a positivity rate as 80% was obtained for aortic aneurysm, although the positivity rate was disappointingly low for left atrial thrombi. No distinct correlation was noted to exist between the degree of accumulation of the tracer in thrombotic lesions and any of factors conceivably of clinical releavance, i. e. time elapsing from onset till testing, thrombolytic medication being given, and hematological factors. 67Ga DFO-DAS-Fibrinogen appeared to be a radiodiagnostic agent that could possibly indicate the existing activity status of thrombosis.
PracticeClinical medicine
KeywordsGa-67 DFO-DAS-Fibrinogen, Thrombus, Clinical evaluation.

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