Japanese
Title99mTc標識赤血球を用いた肺プールシンチグラフィによる肺血流動態の解析
Subtitle原著
Authors林田孝平*
Authors(kana)
Organization*国立循環器病センター放射線診療部
Journal核医学
Volume24
Number4
Page427-439
Year/Month1987/4
Article原著
Publisher日本核医学会
Abstract「要旨」99mTc-赤血球を用いた坐位の肺シンチグラフィ(=肺プールシンチグラフィ)の上・下肺野のカウント比(Pulmonary blood flow ratio=PBF ratio)は99mTc-MAAのそれとの相関が高かった(R=0.91). 僧房弁膜疾患20例でPBF ratioは平均肺動脈圧(R=0.61)および肺血管抵抗(R=0.73)との相関係数が高く, 平均左房圧(R=0.41)では低かった. 酸素負荷(5L/分, 14分)により坐位の肺プールシンチグラフィを行い, 局所肺血流の変化を観察すると僧房弁膜疾患12例および心房中隔欠損症7例では上肺野のカウントが酸素吸入後10分間は有意に減少し, 下肺野のカウントは不変であった. 心房中隔欠損症にて酸素負荷前後の上肺野のカウント減少率と30mmHg未満の平均肺動脈圧との相関係数はR=-0.65であり酸素の影響により肺動脈が収縮したものと考えられた. したがって肺プールシンチグラフィにより肺血流動態の把握とともに肺血管床の病変の広がりの評価ができる.
Practice臨床医学：一般
KeywordsOxygen inhalation test, Pulmonary blood volume, Pulmonary scintigraphy, In vivo Tc-99m RBC labeling, Mitral valvular disease.
English
TitleAnalysis of Pulmonary Blood Flow Dynamics Using Tc-99m Red Blood Cells Pulmonary Scintigraphy
SubtitleOriginal Articles
AuthorsKohei HAYASHIDA
Authors(kana)
OrganizationDepartment of Diagnostic Radiology, National Cardiovascular Center
JournalThe Japanese Journal of nuclear medicine
Volume24
Number4
Page427-439
Year/Month1987/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]The purpose of this study is to evaluate alteration in regional pulmonary blood volume by pulmonary blood flow ratio (=PBF ratio; a ratio of pulmonary count in upper lung field to that in lower lung field) in sitting pulmonary scintigraphy posteriorly using in vivo Tc-99m red blood cells (=RBC). In 9 cases, there was a good correlation (R=0.91) between PBF ratio from Tc-99m RBC pulmonary scintigraphy in sitting position and that from Tc-99m macroaggregated albumin (=MAA) scintigraphy after injection of Tc-99m MAA while sitting. In 20 cases of mitral valvular disease, the correlation between PBF ratio from Tc-99m RBC pulmonary scintigraphy in sitting position and mean left atrial pressure, mean pulmonary arterial pressure, pulmonary arteriolar resistance were R=0.41, R=0.61, R=0.73, respectively. In 12 cases of mitral valvular disease and 8 cases of atrial septal defect, the change of pulmonary blood count (=PBC) of upper and lower pulmonary lung field by Tc-99m RBC pulmonary scintigraphy in sitting position was recorded following oxygen inhalation of 5 liter per minute during 15 minutes. PBC of upper lung field was decreased significantly in mitral valvular disease (p<0.001) and atrial septal defect (p<0.01) during early 10 minutes following oxygen inhalation. Decreased rate of PBC in upper lung field correlated well with mean pulmonary arterial pressure at the range of less than 30 mmHg in atrial septal defect (R=-0.65), but not in mitral valvular disease (R=-0.17). PBF ratio from Tc-99m RBC pulmonary scintigraphy indicated mean pulmonary arterial pressure or pulmonary arteriolar resistance. And decreased blood flow in the lung in atrial septal defect supposed to be attributed to the contraction of pulmonary artery following oxygen inhalation. Tc-99m RBC pulmonary scintigraphy was useful as a means to investigate altered pulmonary circulation for analysis of pulmonary blood flow dynamics and estimating the extent of damage in pulmonary vascular bed.
PracticeClinical medicine
KeywordsOxygen inhalation test, Pulmonary blood volume, Pulmonary scintigraphy, In vivo Tc-99m RBC labeling, Mitral valvular disease.

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