| Japanese |
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| Title | Single photon emission CTによる陽性小病変の検出能 : ファントムおよびシミュレーション実験による検討 |
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| Subtitle | 原著 |
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| Authors | 中嶋憲一*, 久田欣一*, 飯田泰治**, 関宏恭***, 村守朗* |
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| Organization | *金沢大学医学部核医学科, **附属病院アイソトープ部, ***富山医科薬科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 4 |
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| Page | 397-405 |
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| Year/Month | 1987/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Single photon emission CT(SPECT)による陽性小病変の検出能を検討する目的でファントム実験およびコンピュータによるシミュレーション実験を行った. 小病変として直径9から30mmの注射器を胴体ファントム内におき, 病変/バックグラウンド比(T/B比)は2から64まで変化させた. T/B比に関しては, 胴体ファントムの中央においたT/B=4(直径20mm)の病変は認識できた. また, T/B=8ならば, SPECT画像の半値全幅(FWHM)程度の大きさまでは視覚的に検出できた. 病変が小さいときは, 病変部におけるRI濃度とT/B比の過小評価がおきる. コンピュータによるSPECT像のシミュレーション実験では, 減弱やコンプトン散乱を考慮しないとき, SPECT画像のFWHMと同程度の大きさの病変ならば, T/B=2.0まで検出可能であり, 測定されたT/B比も理論値に近かった. これらのデータはSPECT装置の開発や, 新しい放射性医薬品の開発の指標の一つとなると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Single photon emission computed tomography, Hot lesion, Phantom study, Computer simulation. |
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| English |
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| Title | Detectability of Small Hot Lesions in Single Photon Emission Computed Tomography : Experiments Using Phantom and Computer Simulation |
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| Subtitle | Original Articles |
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| Authors | Kenichi NAKAJIMA*, Kinichi HISADA*, Hiroji IIDA**, Hiroyasu SEKI***, Akira MURAMORI* |
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| Authors(kana) | |
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| Organization | *The Department of Nuclear Medicine, **The Division of Radioisotope Service, Kanazawa University School of Medicine, ***The Department of Radiology, Toyama Medical and Pharmaceutical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 4 |
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| Page | 397-405 |
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| Year/Month | 1987/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Detection of small hot lesion is important in nuclear medicine, particularly in nuclear oncology. To evaluate the diagnostic ability of single-photon emission computed tomography (SPECT) in detecting small hot lesion, phantom studies and computer simulation were performed. Small hot lesions from 9 to 30 mm in diameter were located in a body phantom. Target to background ratio (T/B) was changed from 2 to 64. Regarding the T/B ratio, a hot lesion with T/B=4 (20 mm in diameter) which was located in the center of the body could be identified on the SPECT image. As to the size of the object (T/B=8), approximately the size of full-width at half maximum (FWHM) of the imaging system could be detected. When an object was small, significant underestimation of target count and T/B occurred. Because the under-estimation was found even after attenuation correction by Sorenson's method, more appropriate correction may be necessary. In computer simulation of SPECT image, neither attenuation nor Compton's scatter was assumed. When a diameter of the lesion was approximately the same size of the FWHM in the SPECT system, the hot lesion with T/B=2.0 was identified visually on the reconstructed SPECT image. The measured T/B values were nearly equal to theoretical T/B values. These data will be helpful for the development of SPECT system and new radiopharmaceuticals. |
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| Practice | Clinical medicine |
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| Keywords | Single photon emission computed tomography, Hot lesion, Phantom study, Computer simulation. |
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