| Japanese |
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| Title | 放射線肝障害の核医学的観察 |
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| Subtitle | 原著 |
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| Authors | 武中泰樹* |
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| Organization | *昭和大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 4 |
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| Page | 373-381 |
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| Year/Month | 1987/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」放射線の肝に及ぼす影響を検討するために, 家兎の肝左葉に20Gyおよび40Gyの肝臓部分照射を施行し, Tc-99m-スズコロイドおよびTc-99m-EHIDAを用いたシンチグラムにより経時的な追跡とデータ処理装置による解析を行った. その結果, 急性放射線肝障害と慢性放射線肝障害が分離して観察可能であり, それぞれにおける肝細胞とKupffer細胞の変化も分離して観察できた. 放射線肝障害の起こる線量や期間は従来の報告とほぼ一致していたが, より定量的な結果が得られた. RIの取り込みの観察の結果, 急性放射線肝障害での回復はKupffer細胞が肝細胞よりも2日から3日遅く, これは細胞の回復機転の差によるものと考えられる. 局所肝排泄率の障害は線量に依存したが, RIの取り込みとは無関係な変化を示した. その変化は肝内で一様であり, 非照射部においても強い変化を示した. 放射線肝障害に間接的な作用の存在することが示唆される. |
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| Practice | 臨床医学：一般 |
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| Keywords | Liver, Irradiation, Hepatic injury. |
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| English |
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| Title | Evaluation of Radiation Induced Hepatic Injury Using Scintigraphic Methods |
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| Subtitle | Original Articles |
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| Authors | Hiroki TAKENAKA |
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| Authors(kana) | |
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| Organization | Department of Radiology, School of Medicine, Showa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 4 |
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| Page | 373-381 |
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| Year/Month | 1987/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]An experimental study was undertaken to investigate effects of irradiation of the liver. The left liver lobe of the rabbit was irradiated at a single dose of 20 or 40 Gy, and subsequent changes were observed by serial scintigraphy using Tc-99m-Sn-colloid and Tc-99m-EHIDA. The scan images were acquired to data-processor. The uptake ratio of irradiated area to non-irradiated area and regional excretory value (Ke-value) were measured to estimate acute and chronic radiation-induced hepatic injury, respectively. The changes in hepatic cells and Kupffer cells were estimated as well. The data concerning with irradiation dose and duration of the injury showed good agreement with other past reports, though our data was more quantitative than those reports. Recovery of decreased uptake of Tc-99m-Sn-colloid was delayed 2 to 3 days later than that of Tc-99m-EHIDA. The results demonstrated that in acute radiation-induced hepatic injury, recovery of Kupffer cells was delayed more than that of hepatic cells. This discrepancy was considered due to a difference of the repairment between these cell types in acute radiation-induced hepatic injury. The decrease of Ke-value in irradiated area was found to be dose dependent and no relation to regional uptake of EHIDA and Sn-colloid. More-over the decrease of Ke-value was observed even in non-irradiated region, suggesting that liver irradiation may induce an indirect effect. |
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| Practice | Clinical medicine |
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| Keywords | Liver, Irradiation, Hepatic injury. |
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