| Japanese |
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| Title | 肺扁平上皮癌における血清SCC抗原 (Squamous Cell Carcinoma Related Antigen) 測定の臨床的意義 - 特に経過観察における有用性について - |
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| Subtitle | 原著 |
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| Authors | 美濃直子*, 飯尾篤**, 阿多まり子**, 村瀬研也*, 片岡正明*, 伊東久雄*, 石根正博*, 河村正**, 浜本研* |
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| Authors(kana) | |
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| Organization | *愛媛大学医学部放射線科, **附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 2 |
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| Page | 149-156 |
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| Year/Month | 1987/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」原発性肺癌111例について血清SCC抗原を測定し, 扁平上皮癌に対する特異性, 臨床病期や再発との関係, 治療に伴う変化などについて検討した. 血清SCC抗原は肺の扁平上皮癌では, 健常人, 組織型の異なる他の肺癌および良性疾患と比較して, 統計学的に有意に高値となり, 子宮頸部や食道においてと同様に, 肺においても扁平上皮癌に対する特異性が確認された. 臨床病期別では, III, IV期の進行例では, 明らかに高値を示したが, 早期例では半数以上が正常値をとっており, 血清SCC抗原値の測定は早期診断法としては限界が認められた. 一方肺扁平上皮癌について手術や放射線治療を受けた後の血清SCC抗原値の変化は, 腫瘍の縮小程度とよく相関しており, さらに再発の認められた症例では高値となっており, これらの経過観察には有用なマーカーであることが認められた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Squamous cell carcinoma related antigen, Lung cancer, Tumor marker. |
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| English |
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| Title | Usefulness of SCC-antigen for Diagnosis and Monitoring Recurrence and Effectiveness of Therapies of Squamous Cell Carcinoma of the Lung |
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| Subtitle | Original Articles |
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| Authors | Naoko MINO*, Atsushi IIO**, Mariko ATA**, Kenya MURASE*, Masaaki KATAOKA*, Hisao ITO*, Masahiro ISHINE*, Masashi KAWAMURA**, Ken HAMAMOTO* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, School of Medicine, Ehime University, **Division of Central Radiology, Ehime University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 2 |
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| Page | 149-156 |
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| Year/Month | 1987/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The serum levels of SCC antigen (squamous cell carcinoma related antigen) were measured in 111 patients with primary lung cancer to assess its clinical usefulness for diagnosis of squamous cell carcinoma and for monitoring recurrence and effectiveness of therapies. Serum SCC antigen level in patients with squamous cell carcinoma of the lung was 5.9 +- 10.4 ng/ml, which was high (p<0.05) compared with those in normal controls (1.6 +- 0.5 ng/ml), patients with other types of lung cancer (2.4 +- 2.9 ng/ml) or benign disease (1.8 +- 1.1 ng/ml). Studies at various clinical stages of squamous cell carcinoma of the lung showed, however, that the SCC antigen levels were high only in the advanced stages (III and IV), whereas not so high in the earlier stages. These results confirmed that SCC antigen is a relatively specific marker to squamous cell carcinoma in the lung, as reported in the uterine cervix and the esophagus. The SCC antigen levels decreased after operation and more markedly after radiotherapy in dose-dependent manner, corresponding to the reduction of the tumor size. On the other hand, the SCC antigen levels were extremely high in the recurrence. It was concluded that SCC antigen is a useful marker for monitoring recurrence or effectiveness of the therapies of SCC of the lung, although not so for its early diagnosis. |
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| Practice | Clinical medicine |
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| Keywords | Squamous cell carcinoma related antigen, Lung cancer, Tumor marker. |
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