| Japanese |
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| Title | 負荷試験時ポジトロンCTによる局所脳血流, 脳酸素代謝の測定とその有効性の検討 |
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| Subtitle | 原著 |
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| Authors | 棚田修二*, 米倉義晴*, 千田道雄*, 佐治英郎*, 藤田透*, 鳥塚莞爾*, 小林映**, 滝和郎**, 石川正恒**, 半田肇**, 原田清***, 福山秀直***, 亀山正邦*** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線核医学科, **脳神経外科, ***神経内科 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 2 |
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| Page | 125-135 |
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| Year/Month | 1987/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」15O標識ガス吸入法によるポジトロンCT検査により, グリセロールおよび二酸化炭素吸入負荷に対する健常部大脳皮質の脳血流(CBF), 脳酸素代謝(CMRO2)の変動について検討した. グリセロール負荷試験では14例中10例に血流増加が認められた. 頭蓋内圧亢進のあった6例では, 低酸素代謝の改善が見られ, 酸素代謝を正常域に保とうとする機構の存在が考えられた. 5%二酸化炭素吸入負荷試験では, 脳梗塞4例でCBFの著明な増加があり良好な血管反応性を示したが, CMRO2の変化は一定せず, かつその変化は少なかった. これに対してモヤモヤ病の4例ではCBF, CMRO2, 酸素摂取率(OEF)ともに変化が認められず, 二酸化炭素に対する脳血管反応性の欠如が示された. ポジトロンCTは, 各種負荷試験によるCBF, CMRO2の変化の評価にすぐれていると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission tomography, Cerebral blood flow, Cerebral oxygen metabolism, Glycerol, Carbon dioxide. |
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| English |
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| Title | Clinical Usefulness of Positron Emission Tomography in the Evaluation of Regional Cerebral Blood Flow and Cerebral Oxygen Metabolism Under Glycerol and Carbon Dioxide Loadings |
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| Subtitle | Original Articles |
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| Authors | Shuji TANADA*, Yoshiharu YONEKURA*, Michio SENDA*, Hideo SAJI*, Toru FUJITA*, Kanji TORIZUKA*, Akira KOBAYASHI**, Waro TAKI**, Masatsune ISHIKAWA**, Hajime HANDA**, Kiyoshi HARADA***, Hidenao FUKIYAMA***, Masakuni KAMEYAMA*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, **Department of Neurosurgery, ***Department of Neurology, Kyoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 2 |
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| Page | 125-135 |
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| Year/Month | 1987/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Cerebral blood flow (CBF) and oxygen metabolism (CMRO2) were studied in normal cerebral cortices by positron emission tomography using continuous inhalation method of oxygen-15 labeled carbon dioxide and oxygen, and single inhalation method of oxygen-15 labeled carbon monoxide. The values of CBF, CMRO2, and oxygen extraction fraction (OEF) in cerebral cortices of 18 healthy normal volunteers represented 40 +- 7 ml/ 100 ml/min, 3.2 +- 0.5 ml O2/100 ml/min, and 0.43 +- 0.07, respectively. In cases with glycerol loading, CBF increased in 10/14 cases. Studies of 6 cases with intracranial pressure indicated the presence of mechanism by which depressed CMRO2 improved and was kept in normal values. The loading of 5% carbon dioxide showed an increase in CBF in cases with cerebral infarction, which implied the good cerebral vascular response to the elevated arterial carbon dioxide, but no particular changes were observed in CMRO2 which seemed to be less responsive to the elevated arterial carbon dioxide level. In cases with moyamoya disease, 5% carbon dioxide loading showed no changes in CBF and CMRO2. This suggested the poor cerebral vascular response to the elevation of arterial carbon dioxide, while X-ray CT failed to demonstrate any abnormalities in corresponding areas. Positron emission tomography proved to have a great potentiality regarding the evaluation of the changes in cerebral blood flow and cerebral oxygen metabolism under various loadings. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission tomography, Cerebral blood flow, Cerebral oxygen metabolism, Glycerol, Carbon dioxide. |
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