| Japanese |
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| Title | 下肢閉塞性動脈硬化症における血小板シンチグラフィーの有用性に関する検討 - Indium-111 Platelet Scintigraphy in Arteriosclerosis Obliterans of the Lower Limbs - |
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| Subtitle | 原著 |
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| Authors | 北川一夫*, 宮井元伸*, 恵谷秀紀***, 井坂吉成***, 上原章***, 田中健一*, 濱中康彦*, 額田忠篤*, 宇治茂**, 米田正太郎****, 木村和文*** |
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| Authors(kana) | |
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| Organization | *国立大阪南病院循環器科, **放射線科, ***大阪大学医学部中央放射線部, ****第一内科学教室 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 2 |
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| Page | 115-123 |
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| Year/Month | 1987/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」下肢閉塞性動脈硬化症(ASO)の閉塞性血管病変部位における血小板集積の有無を, 111In-血小板と99mTc-人血清アルブミンを用いた2核種シンチグラフィーで評価し, 血管造影所見と対比した. 抗血小板療法未実施時にシンチグラフィーを施行したASO 8例(血管造影上の閉塞性病変部13か所)のうち, 5例5か所で血小板集積陽性を示した. その陽性を示した5例のうち, アスピリン(650mg/日)治療を3週間実施した後, シンチグラフィーを再検しえた3例では, 陽性病変部位はすべて陰性化した. 本法は, ASO個々の症例での血小板集積の評価と, 抗血小板療法の生体内での効果判定に有用であると考えられた. 「I. はじめに」動脈硬化の進展および動脈血栓症の発生に血小板が重要な役割を担っていることが知られている. 従来, 動脈血栓症における血小板集積を体外より測定することは困難であったが, 1976年にThakurらが111In-oxineを用いた血小板標識法を開発して以来, 標識血小板の生体内分布を体外計測することが可能となり種々の血栓性病変の評価が行われている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Arteriosclerosis obliterans, In-111 labeled platelet, Tc-99m human serum albumin, Antiplatelet therapy, Aspirin. |
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| English |
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| Title | Detection of Platelet Deposition in Cases of Arteriosclerosis Obliterans (ASO) Using Indium-111 Platelets and Tc-99m Human Serum Albumin |
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| Subtitle | Original Articles |
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| Authors | Kazuo KITAGAWA*, Motonobu MIYAI*, Hideki ETANI**, Yoshinari ISAKA**, Akira UEHARA**, Kenichi TANAKA*, Yasuhiko HAMANAKA*, Tadaatsu NUKADA*, Shigeru UJI***, Syoutarou YONEDA****, Kazufumi KIMURA** |
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| Authors(kana) | |
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| Organization | *Department of Cardiovascular Disease, National Osaka-minami Hospital, **The Division of Nuclear Medicine, Osaka University Medical School, ***Department of Radiology, National Osaka-minima Hospital, ****The First Department of Internal Medicine, Osaka University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 2 |
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| Page | 115-123 |
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| Year/Month | 1987/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We evaluated platelet deposition in vivo it 10 patients with arteriosclerosis obliterans (ASO; of the lower limbs and 8 normal subjects with a dual-tracer technique using indium-111 platelet and Tc-99m human serum albumin. Each patient with ASO showed intermittent claudication and angiographically occlusive vascular lesions in either the aorta, common iliac artery, external iliac artery, internal iliac artery or femoral artery. Of the 8 patients who were not under antiplatelet medication, 5 showed positive platelet deposition at angiographically occlusive vascular sites, where-as none of the normal subjects showed in vivo platelet deposition. In three patients who showed platelet deposition without antiplatelet medication and thereafter received aspirin therapy (650 mg/day), platelet deposition at all occlusive vascular sites was resolved after aspirin therapy. This preliminary study indicated that platelet scintigraphy might be useful in evaluating thrombogenicity and the effect of antiplatelet medication in vivo, in patients with ASO. |
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| Practice | Clinical medicine |
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| Keywords | Arteriosclerosis obliterans, In-111 labeled platelet, Tc-99m human serum albumin, Antiplatelet therapy, Aspirin. |
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