| Japanese |
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| Title | 脳腫瘍におけるN-isopropyl- [I-123] p-iodoamphetamineによる局所脳血流SPECTの意義 |
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| Subtitle | 原著 |
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| Authors | 西澤貞彦*, 棚田修二*, 藤田透*, 米倉義晴*, 千田道雄*, 石川正恒**, 鳥塚莞爾* |
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| Organization | *京都大学医学部放射線核医学科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 24 |
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| Number | 1 |
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| Page | 15-25 |
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| Year/Month | 1987/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-[I-123]p-iodoamphetamine(IMP)静注直後から2分間のSPECTを連続して8回(dynamic scan)と, 静注後20分および5時間から30分間のSPECT(early scan, late scan)を行うことにより, IMPの脳腫瘍における早期の動態および腫瘍, あるいはその周辺における経時的変化を検討した. さらにポジトロンCT(PET)を用いて血流を測定できた4症例においては, 血流分布とIMPの分布とを比較した. 7例においてdynamic scanで腫瘍に一致するIMPの集積増加を認め, うちPETを行った2例で同様に腫瘍部の血流増加が示された. また低集積を示した腫瘍においてもPETを施行した2例では同様の血流低下が示された. early scanで低集積を示した腫瘍周囲の浮腫および遠隔部にはlate scanで再分布が認められたが, 腫瘍部には再分布は見られなかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain tumor, Single-photon emission computed tomography, N-isopropyl-[I-123]p-iodoamphetamine, Positron emission tomography, Cerebral blood flow. |
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| English |
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| Title | Value of Regional Cerebral Perfusion SPECT with N-Isopropyl- (I-123)p-Iodoamphetamine (IMP) in Brain Tumors |
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| Subtitle | Original Articles |
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| Authors | Sadahiko NISHIZAWA*, Shuji TANADA*, Toru FUJITA*, Yoshiharu YONEKURA*, Michio SENDA*, Masatsune ISHIKAWA**, Kanji TORIZUKA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, Kyoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 24 |
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| Number | 1 |
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| Page | 15-25 |
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| Year/Month | 1987/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate early dynamics and late changes of IMP distribution in brain tumors and surrounding tissues, we performed serial single photon emission computed tomography (SPECT); eight 2-min scans (dynamic scan) immediately after IMP administration and two 30-min scans at 20 min (early scan) and 5 hr (late scan) after injection. We also measured cerebral blood flow (CBF) in 4 cases using positron emission tomography and 0-15 labeled carbon dioxide or water, and compared the distribution of IMP with CBF. Seven tumors out of 24 studies showed increased accumulation of IMP on the dynamic scan, indicating high blood flow, but the activity decreased rapidly in the tumor and all tumors showed decreased uptake on the late scan. The initial distribution of IMP in the tumor showed similar pattern as CBF measured by PET. In the early scan, decreased accumulation was observed in the more extended area than tumors visualized by XCT, probably including the area of perifocal edema. On the late scan, redistribution of the tracer was observed in the area of edema. In one case with right thalamic glioma, decreased uptake of the tracer was shown in the cortex of right cerebral hemisphere on the early scan, indicating transneuronal suppression, but no laterality was found on the late scan. There was no redistribution of the tracer in the tumor. In summary, only the initial distribution of IMP can show the blood flow in brain tumors, and routine SPECT with rotating gamma camera available in most institutions may fail to detect it. Late scan may be useful for delineating the tumor extention. |
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| Practice | Clinical medicine |
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| Keywords | Brain tumor, Single-photon emission computed tomography, N-isopropyl-[I-123]p-iodoamphetamine, Positron emission tomography, Cerebral blood flow. |
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