| Japanese |
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| Title | 聴覚刺激によるN-Isopropyl-p- [I-123] Iodoamphetamineの脳内分布の変動 - 局所脳血流測定の立場から - |
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| Subtitle | 《研究速報》 |
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| Authors | 賈少微*, 小田野幾雄*, 土屋俊明*, 酒井邦夫* |
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| Authors(kana) | |
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| Organization | *新潟大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 11 |
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| Page | 1619-1624 |
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| Year/Month | 1986/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」生理的刺激を負荷した場合の脳局所の代謝や血流量の変化をとらえることは, 生理学的にも, 診断学的にも重要なことである. 1980年, Winchellらによって開発されたN-Isopropyl-p- [I-123] Iodoamphetamine (以下I-123 IMPと略す) は初期分布が脳血流の分布とよく相関することから, 脳血流測定用薬剤として脳血管障害の血流評価に用いられている. ところが, 本剤を用いて生理的負荷を与えた場合の脳血流の変化をとらえた報告は少なく, 光刺激による変化をとらえたHillらと指運動および音読による変化をとらえた松田らの報告をみるのみである. 今回われわれは, 若い正常人に4種類の聴覚刺激を負荷し, 持続動脈採血をしながら回転型ガンマ・カメラを用いて脳局所血流を測定し, その変化を検討したので報告する.「II. 対象と方法」[1) 対象, 装置および撮像条件] 対象は正常人男子ボランティア8名 (年齢21〜37歳平均25.6歳, 正常コントロール4名, 聴覚刺激4名) である. 甲状腺ブロックのためI-123 IMP静注前日より連日5日間ルゴール液を内服させた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Regional cerebral blood flow, Auditory stimulation, N-isopropyl-p- (I-123) iodoamphetamine, SPECT. |
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| English |
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| Title | Measurement of Regional Cerebral Blood Flow Using N-Isopropyl-p-(I-123) Iodoamphetamine ; Changes by Auditory Stimulation |
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| Subtitle | |
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| Authors | Shao-Wei JIA, Ikuo ODANO, Toshiaki TSUCHIYA, Kunio SAKAI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Niigata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 11 |
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| Page | 1619-1624 |
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| Year/Month | 1986/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : N-isopropyl-p- (I-123) iodoamphetamine (I-123 IMP) is a radiopharmaceutical that is lipid-soluble, penetrates the normal blood-brain barrier, and has a high first-pass extraction efficiency in brain. The initial I-123 IMP distribution is known to be related to local cerebral blood flow (rCBF) . When combined with single-photon emission computed tomography (SPECT) , rCBF can be measured by a modified method of arterial blood sampling. On eight male volunteers, whole-brain CBF was measured ; four were normal control in unstimulating state and the other four were loaded with auditory stimulation. Average of whole-brain CBF of four normal control subjects was 49.5+-4.7 ml/100 g brain/min .In four subjects loaded with auditory stimuli, the accumulation of I-123 IMP was not increased in the left temporal cortex. It was speculated that the strength of the auditory stimulation was not enough to cause change of I-123 IMP distribution in the brain, or there might be another unknown reason to bring about the hypoperfusion in the left temporal cortex. |
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| Practice | Clinical medicine |
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| Keywords | Regional cerebral blood flow, Auditory stimulation, N-isopropyl-p- (I-123) iodoamphetamine, SPECT. |
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