| Japanese |
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| Title | 111In標識モノクローナル抗体 (96.5) によるメラノーマイメージングの試み |
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| Subtitle | 《原著》 |
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| Authors | 小山田日吉丸*, 石原和之**, 早坂健一**, 照井頌二*, 福喜多博義*, 舘野之男*** |
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| Organization | *国立がんセンター放射線診断部RI診断, **国立がんセンター皮膚科, ***放射線医学総合研究所臨床研究部 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 11 |
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| Page | 1595-1611 |
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| Year/Month | 1986/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: 米国Hybritech社製の抗ヒト・メラノーマ・マウス・モノクローナル抗体 (96.5) を111Inで標識し (111In-MoAb) , 悪性黒色腫11例と基底細胞癌1例の計12例にイメージングを行った. 悪性黒色腫では大小多数の病巣をもった1例で描出不成功であったが, 残りの10例はいろいろな程度に集積を示した. 6例については67Ga-citrateでも検討された. 両者はほぼ似たような成績で, あわせると僅かに検出率は向上した. 炎症の合併していた1例では67Ga-citrateで強い集積がみられ, 111In-MoAbでは淡い集積しか認められなかった. 組織検査では腫瘍細胞が散在していたにすぎず, 111In-MoAbの結果を裏づけていた. しかしInterleukin 2の注射部位には111In-MoAbの非特異的集積が認められた (false positive) . 基底細胞癌の1例では淡い集積が認められた. あわせて免疫イメージングについての考察も行った. |
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| Practice | 臨床医学：一般 |
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| Keywords | Monoclonal antibody, Melanoma, Radioimmunoimaging, Scintigraphy. |
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| English |
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| Title | Clinical Trials of Melanoma Imaging with In-111-labeled Monoclonal Antibody 96.5 |
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| Subtitle | Original Articles |
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| Authors | Hiyoshimaru OYAMADA*, Kazuyuki ISHIHARA**, Kenichi HAYASAKA**, Shoji TERUI*, Hiroyoshi FUKUKITA*, Yukio TATENO*** |
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| Organization | *Radioisotope Diagnosis, Department of Diagnostic Radiology, National Cancer Center Hospital, **Department of Dermatology, National Cancer Center Hospital, ***National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 11 |
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| Page | 1595-1611 |
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| Year/Month | 1986/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : Eleven cases with malignant melanoma and one case with basal cell carcinoma were studied with In-111-1abeled anti-human melanoma mouse monoclonal antibody (MoAb 96.5) which was supplied by Hybritech Co. In one case of melanoma with various-sized multiple lesions spread over the body, imaging failed to detect any lesion. In the remaining 10 cases, however, accumulations were noted in various degrees. In 6 cases, Ga-67 scintigraphy was performed in addition, and the results of both techniques were comparable, and the detectability was slightly raised when both techniques were taken into considerations. In one case, the area of coexisting inflammation was strongly positive with Ga-67 but slightly positive with In-111-MoAb. Histological examination revealed only scanty tumor cells, consistent with the result of the imaging using In-111-MoAb. However, another case showed a moderate accumulation of In-111-MoAb in the area where Interleukin 2 was repeatedly injected. This was thought to be non-specific accumulation of In-111-MoAb (false positive) . One case of basal cell carcinoma showed a mild accumulation. Also, a brief discussion was made on radioimmunoscintigraphy. |
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| Practice | Clinical medicine |
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| Keywords | Monoclonal antibody, Melanoma, Radioimmunoimaging, Scintigraphy. |
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