Japanese
Title職業性肺疾患におけるエアロゾル肺吸入シンチグラフィ
Subtitle《原著》
Authors須井修*
Authors(kana)
Organization*徳島大学医学部放射線医学教室
Journal核医学
Volume23
Number11
Page1553-1563
Year/Month1986/11
Article原著
Publisher日本核医学会
Abstract「要旨」: ゴム製造作業従事者28名, マンガン精錬作業従事者16名およびクロム塩作業従事者11名の多年作業従事者55症例について, エアロゾル肺吸入シンチグラフィを施行した. 肺吸入イメージでは, ゴム製造作業従事者の12例 (43%) , マンガン精錬作業従事者の7例 (46%) に不均一な肺内沈着分布を認めた. "peripheral penetration index (PPI) " を用いた半定量的評価では, PPIは対照群とゴム製造作業従事者, マンガン精錬作業従事者の間に差がみられた. じん肺法による胸部X線写真の型の区分とPPIの間では, 0型, 第1型に差が認められた. PPIはV50/HT, V25/HT, V50/V25より異常出現率が高く, じん肺症の呼吸機能障害の早期発見に有用と考えられた. クロム塩作業従事者では, early imageとdelayed imageの比較で3例に気道粘膜線毛運動の異常が発見され, 組織学的に異型のある扁平上皮化生が証明された.
Practice臨床医学：一般
KeywordsAerosol lung inhalation scintigraphy, Occupational lung disease, Talcosis, Manganoconiosis, Chromate worker.
English
TitleAerosol Lung Inhalation Scintigraphy in Occupational Lung Disease
SubtitleOriginal Articles
AuthorsOsamu SUI
Authors(kana)
OrganizationDepartment of Radiology, School of Medicine, Tokushima University
JournalThe Japanese Journal of nuclear medicine
Volume23
Number11
Page1553-1563
Year/Month1986/11
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] : Aerosol lung inhalation scintigraphy with 99mTc-millimicrosphere albumin was performed in 55 cases with occupational lung disease. Twenty-eight cases were rubber workers, sixteen were manganese workers and eleven were chromate workers. Aerosol inhalation images in rubber and manganese workers were evaluated qualitatively and semiquantitatively. In qualitative evaluation, inhomogeneous distribution of aerosol particles was observed in 12 cases out of 28 rubber workers and in 7 cases out of 16 manganese workers. A "peripheral penetration index (PPI) " was defined as the ratio of the peripheral to the central counts normalized by the corresponding areas. The mean value of PPI for normal subjects was 0.55+-0.04 (s.d.) . The mean values for rubber and manganese workers were 0.49+-0.06, 0.49+-0.02, respectively (p<0.05) . Those for PR0 and PR1 groups in rubber workers were 0.48+-0.02, 0.49+-0.04, respectively (p<0.01) ,but the mean values for PR2 and PR3 groups in rubber workers were not significantly lower than those of the normal subjects. The sensitivities for small airway disease detection were 43% for V50/HT, 36% for V25/HT and 39% forV50/V25 in a maximum forced expiratory flow-volume curve, but the sensitivity was 68% for PPI. These results indicate that the value of PPI is usuful for early detection of small airway disease. In chromate workers, both early and delayed inhalation images were useful for evaluation of mucociliary clearance. Excessive central airway deposition on both images was seen in 3 cases out of 11 chromate workers, and two of them were detected pathohistologically squamous cell metaplasia with atypia in bronchial epithelium. Two years later, lung cancer was found in just one case out of them.
PracticeClinical medicine
KeywordsAerosol lung inhalation scintigraphy, Occupational lung disease, Talcosis, Manganoconiosis, Chromate worker.

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