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| Title | Radionuclide Study on Hepatic Blood Flow in Schistosomiasis Japonica |
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| Subtitle | Original Articles |
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| Authors | Junichi OKADA*, Guio UCHIYAMA*, Kazushige HAYAKAWA*, Sanshin HAYASHI*, Tsutomu ARAKI*, Takao ARAI*, Masahiko IUCHI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Yamanashi University School of Medicine, **Kofu City Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 11 |
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| Page | 1517-1522 |
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| Year/Month | 1986/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Abstract] : Schistosomiasis Japonica is a regional disease found in elderly people who were living in once-endemic areas in Japan. Yamanashi was one of these areas until 1970, since when no newly infected patients were reported. The disease is characteristic of developing irreversible interstitial fibrosis of the liver, where parasites migrate and lay eggs. Portal hypertension, esophageal varices and hepatocellular carcinomas are the common features of the results. In order to estimate patient's hepatic blood flow, radionuclide angiography of the liver with the use of 10-15 millicuries of Tc-99m phytate were performed prior to the conventional multiview imaging. Twenty-two patients with schistosomiasis and twelve adults without evidence of liver disease were studied. A time-activity curve of the right lobe of the liver was generated by a computer, and the ratio of arterial blood flow to portal blood flow was calculated. As a result, a good correlation was found between the arteria to portal blood flow ratio and the grade of hepatic fibrosis verified by laparoscopic biopsy. The development of esophageal varices were likely to correlate well with the blood flow ratio rather than scores on the conventional static liver and spleen scintigram. The study was useful for evaluating patient's clinical stages and prognosis. |
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| Practice | Clinical medicine |
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| Keywords | Schistosomiasis Japonica, Hepatic blood flow, Liver scintigram, Radionuclide angiography, Esophageal varices. |
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| Japanese |
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| Title | 肝RIアンジオグラフィーを用いた慢性日本住血吸虫症肝の血流動態解析 |
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| Subtitle | 《原著》 |
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| Authors | 岡田淳一*, 内山暁*, 早川和重*, 林三進*, 荒木力*, 新井誉夫*, 井内正彦** |
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| Authors(kana) | |
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| Organization | *山梨医科大学放射線医学教室, **甲府市立病院 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 11 |
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| Page | 1517-1522 |
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| Year/Month | 1986/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: 日本住血吸虫症の感染後数か月から数年して生じる肝の線維化は不可逆的な変化であり肝癌や門脈圧亢進症の発生母地となるため, 本疾患における肝の病態解析やいったん罹患した者の管理はなお重要な問題である. 今回われわれは慢性日本住血吸虫症患者22例, 正常者12例を対象とし肝の血流動態解析を行った. 99mTc-フチン酸10〜15mCiを急速静注し肝に関心領域をおいた時間放射能曲線を解析することにより肝動脈の門脈に対する血流比 (b/a値) の算出した. 病理所見上肝の線維化が強いほどb/a値は低下する傾向にあり, 食道静脈瘤の有無に関しては従来の肝シンチグラム静態像による評価よりも優れた相関を示した. 慢性日本住血吸虫症の重症度判定, 予後の評価にb/a値は有用な指標である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Schistosomiasis Japonica, Hepatic blood flow, Liver scintigram, Radionuclide angiography, Esophageal varices. |
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