| Japanese |
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| Title | 虚血心筋におけるフルオロデオキシグルコースの集積 (第1報) - 安静時および運動負荷時心筋血流との比較 - |
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| Subtitle | 《原著》 |
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| Authors | 米倉義晴*, 千田道雄*, 小出治敏*, 佐治英郎*, 山本和高*, 西澤貞彦*, 鳥塚莞爾*, 不藤哲郎**, 橋本哲男**, 神原啓文**, 河合忠一**, 小西裕***, 伴敏彦*** |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, **第三内科, ***心臓血管外科 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 10 |
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| Page | 1361-1367 |
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| Year/Month | 1986/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: 虚血心筋におけるブドウ糖代謝の評価を目的として, ポジトロン断層法 (PET) を用いて, 安静・絶食時における18F-フルオロデオキシグルコース (FDG) の集積を, 13N-アンモニアによる安静時および運動負荷時の心筋血流分布と比較して検討した. FDGは, 安静時虚血部のみならず, 比較的新しい心筋梗塞部や梗塞周囲の虚血部, あるいは運動負荷により誘発される虚血部にも集積を示した. またこのFDGの集積には, バイパス手術により正常化する可逆的な変化を認めた例もあった. 虚血心筋におけるFDGの集積は, 従来より言われてきた単なる嫌気的解糖系の亢進によるのみならず, グリコーゲンの蓄積など他の複雑な要因の関与も考えられ, 今後その病態解明が必要と思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Myocardial ischemia, Positron emission tomography, Myocardial metabolism, F-18 fluorodeoxyglucose. |
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| English |
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| Title | Accumulation of Fluorodeoxyglucose in Ischemic Myocardium - I. Comparison with Myocardial Perfusion at Rest and during Exercise - |
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| Subtitle | Original Articles |
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| Authors | Yoshiharu YONEKURA*, Michio SENDA*, Harutoshi KOIDE*, Hideo SAJI*, Kazutaka YAMAMOTO*, Sadahiko NISHIZAWA*, Kanji TORIZUKA*, Tetsuro FUDO**, Tetsuo HASHIMOTO**, Hirofumi KAMBARA**, Chuichi KAWAI**, Yutaka KONISHI***, Toshihiko BAN*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Third Division, Department of Internal Medicine, ***Department of Cardiovascular Surgery, Kyoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 10 |
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| Page | 1361-1367 |
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| Year/Month | 1986/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : In order to evaluate glucose metabolism in is chemic myocardium, we compared regional accumulation of 18F-fluorodeoxyglucose (FDG) with myocardial perfusion at rest and during exercise using positron emission tomography (PET) . Myocardial perfusion PET scan was performed with intravenous injection of 13N-ammonia at rest and during supine exercise on ergometer. FDG PET study was performed at rest with fasting. Increased accumulation of FDG was shown in the area with recent myocardial infarction, peri-infarcted region and stress induced ischemic myocardium, as well as myocardial region with resting hypoperfusion. This increased accumulation of FDG was reversible after bypass grafting in a case with effort angina. These results suggest increased influx of FDG in ischemic myocardium, which may be due to the active glycolysis and/or other factors such a glycogen storage. |
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| Practice | Clinical medicine |
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| Keywords | Myocardial ischemia, Positron emission tomography, Myocardial metabolism, F-18 fluorodeoxyglucose. |
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