| Japanese |
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| Title | 骨シンチグラフィーによるラット移植関節の骨生着に関する評価 |
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| Subtitle | 《原著》 |
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| Authors | 藤森研司*, 佐久間隆**, 伊藤和夫*, 古舘正従*, 三浪明男**, 荻野利彦** |
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| Authors(kana) | |
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| Organization | *北海道大学医学部核医学講座, **整形外科学講座 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 10 |
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| Page | 1343-1350 |
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| Year/Month | 1986/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: ラットの膝関節移植後の骨シンチグラフィーの経時的変化を定量的に解析し, 移植関節の生着に関する影響を移植法と主要組織適合抗原の2点より検討した. 主要組織適合抗原 (RT1) の異なる純系ラット5系を用い, 対象を血管柄付自家関節移植群 (I群, n=8) , 非血管柄付自家関節移植群 (II群, n=10) , 非血管柄付同種関節移植群 (III群, n=26) の3群に分けて検討した. 膝関節部の集積はI群では1週目で高値が観察され, II群とIII群ではともに低値であった. II群ではIII群よりも骨集積はやや早く上昇しはじめ, この時期の組織学的変化としてrevascularizationが観察された. 骨接合部に関してはI, II群では骨のremodelingを反映した集積像が観察され, I群では集積亢進が持続した. 一方, III群では2-4週目に一過性の集積亢進が観察され, この現象は組織学的対応から拒絶反応を示唆するものと考えられた. 骨シンチグラフィーは関節移植の評価に有用であり, 経時的な観察により術後の血管閉塞や拒絶反応を評価し得ると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Bone scintigraphy, Joint transplantation, Vascularization, Major histocompatibility antigen. |
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| English |
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| Title | Evaluation of Survival of Grafted Joint by Bone Scintigraphy : Experimental Studies Using Rat Models |
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| Subtitle | Original articles |
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| Authors | Kenji FUJIMORI*, Takashi SAKUMA**, Kazuo ITOH*, Masayori FURUDATE*, Akio MINAMI**, Toshihiko OGINO** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Orthopedics, University of Hokkaido, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 10 |
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| Page | 1343-1350 |
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| Year/Month | 1986/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : To evaluate survival of grafted joint, bone scintigraphy with 99mTc-MDP was performed in using five inbred rats. These rats were further grouped to three according to different bone implantation, vascularized autogenic grafts (Group-I) , non-vascularized autogenic grafts (Group-II) and non-vascularized allogenic grafts (Group-III) . Bone scintigraphy of Group-I showed immediately high uptake throughout the grafted joint and the junction of the femur after the transplantation which was persisted until 10 weeks. In Group-II and Group-III, bone uptake at the end of the femur were gradually elevated in time after the transplantation. A subgroup in Group-III which had the most different combination in the major histocompatibility antigen showed transient high bone uptake at the junction of recipient femur at 2 to 4 weeks after the transplantation. This phenomena could be related to rejection due to difference of the major histocompatibility which was also seen histologically. Bone scintigraphy is useful to evaluation of survival of grafted joint and it could be able to evaluate accidents after bone graft such as vascular occulsion and rejection by serial studies. |
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| Practice | Clinical medicine |
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| Keywords | Bone scintigraphy, Joint transplantation, Vascularization, Major histocompatibility antigen. |
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