| Japanese |
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| Title | POSITOLOGICA-IIを用いた全身スキャン方式の開発とその性能評価 |
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| Subtitle | 《原著》 |
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| Authors | 遠藤真広*, 松本徹*, 飯沼武*, 篠遠仁*, 山崎統四郎*, 舘野之男*, 大串明**, 熊本三矢戒** |
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| Organization | *放射線医学総合研究所臨床研究部, **日立メディコ(株) |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 8 |
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| Page | 1025-1036 |
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| Year/Month | 1986/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: 多段円形リング型の全身用ポジトロンCT装置POSITOLOGICA-IIを用い, 通常のサンプリングに寝台天板の移動を組合わせてポジトロン核種の全身スキャンを行う方式を開発した. 本方式をシンチレーションカメラによる測定と比較したところ, 感度は劣るが空間分解能において格段に優れていることがわかった. また, 本方式の空間分解能は理論的な予測とほぼ一致した. 本方式により, トレーサーの生体内挙動についておおよその情報を得ることができ, 新しい薬剤を開発した場合などに有効と考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Whole body emission scannography, Positron emission tomography, Performance evaluation. |
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| English |
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| Title | Development and Performance Evaluation of Whole Body Emission Scannography with POSITOLOGICA-II |
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| Subtitle | Original Articles |
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| Authors | Masahiro ENDO*, Toru MATSUMOTO*, Takeshi A. IINUMA*, Hitoshi SHINOTO*, Toshio YAMASAKI*, Yukio TATENO*, Akira OGUSHI**, Miyakai KUMAMOTO** |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, National Institute of Radiological Scienses, **Hitachi Medical Corporation |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 8 |
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| Page | 1025-1036 |
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| Year/Month | 1986/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : Whole body scannography for positron-emitting nuclides was developed using combination of a scanning mechanism and bed translation of POSITOLOGICA-II, a whole body positron emission tomograph with multi-ring detectors. The present method has four modes of bed translation with sampling pitches of 6, 12, 18, 36 mm. Sensitivity for a plane source and spatial resolution of the present method were measured and compared with the results obtained by single photon (511keV) detection with a scintillation camera. The sensitivity was 0.077-0.104 cps/μCi per projection, depending on sampling pitches, for the present method and 24.3 cps/μCi for the scintillation camera. The full widths at half maximum of line spread function were 9.5 mm (transverse) and 13mm (axial) for the best sampling condition of the present method and 104 mm for the scintillation camera. The spatial resolution of the present method agreed fairly well with theoretical estimation. Scannorgrams of a normal volunteer were taken by the present method after intravenous injection of N-13 ammonia solution. In spite of a very low sensitivity, the scannograms clearly showed accumulations of N-13 activities with an appropriate resolution. It was concluded that the present method can give a distribution and slow dynamics of positron-emitting nuclides in vivo with a much higher spatial resolution than the scintillation camera and it may be useful for analyzing behaviours of new positron-emitting radiopharmaceuticals in man. |
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| Practice | Clinical medicine |
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| Keywords | Whole body emission scannography, Positron emission tomography, Performance evaluation. |
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