| Japanese |
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| Title | アシアロ糖タンパク - アシアロ糖タンパク受容体系を応用した新しい肝機能検査法の開発 - 第1報 99mTc標識ネオ糖タンパクによる肝イメージングの検討 - |
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| Subtitle | 《原著》 |
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| Authors | 久保田佳嗣*, 小島通真**, 羽間弘*, 河相吉**, 中沢緑**, 西山豊**, 中川三郎**, 村瀬登志彦*, 奥野裕康*, 内藤雄二*, 鷲野弘明****, 長谷川武夫**, 沢村隆也*, 田代裕***, 田中敬正**, 塩崎安子*, 鮫島美子* |
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| Authors(kana) | |
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| Organization | *関西医科大学第三内科, **放射線科, ***第一生理, ****日本メジフィジックス社 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 7 |
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| Page | 899-905 |
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| Year/Month | 1986/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: アシアロ糖タンパク (asialoglycoprotein : ASGP) - ASGP受容体系を用いて肝のイメージングを行う, 新しい肝のRI検査法の有用性について検討した. ASGPと等価にASGP受容体と結合し, 肝臓に取り込まれるネオ糖タンパクに, SnCl2を還元剤として99mTcを標識し, 正常家兎ならびに3'-メチル-4-ジメチルアミノアゾベンゼン (3'-Me-DAB) 肝癌ラットに投与して, シンチグラムを作製した. 正常家兎における肝イメージングでは, 99mTc-Auコロイドに比べて, 遜色のない像が得られた. また, 肝癌ラットでも, 直径10mm大の腫瘤が, 周囲とのコントラストが明瞭な欠損像として描出され, 肉眼所見とも良く一致した. また, ラット肝癌の癌部および非癌部のASGP受容体活性を測定した結果, 肝癌組織中には受容体活性が検出されないことが明らかとなり, シンチグラムの欠損像が裏づけられた. 以上の成績により, 99mTc標識ネオ糖タンパクによる肝のイメージングは, 有用な肝RI検査法の一つになると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | A sialoglycoprotein, Asialoglycoprotein receptor, Neoglycoprotein, Liver scintigram. |
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| English |
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| Title | A New Liver Function Test Using the Asialoglycoprotein-receptor System on the Liver Cell Membrane : I. Evaluation of Liver imaging Using the Tc-99m-Neoglycoprotein |
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| Subtitle | Original Articles |
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| Authors | Yoshitsugu KUBOTA*, Michimasa KOJIMA**, Hiroshi HAZAMA*, Soukichi KAWA**, Midori NAKAZAWA**, Yutaka NISHIYAMA**, Saburo NAKAGAWA**, Toshihiko MURASE*, Hiroyasu OKUNO*, Yuji NAITOH*, Koumei WASHINO****, Takeo HASEGAWA**, Takaya SAWAMURA*, Yutaka TASHIRO***, Yoshimasa TANAKA**, Yasuko SHIOZAKI*, Yoshiko SAMESHIMA* |
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| Authors(kana) | |
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| Organization | *The Third Department of Internal Medicine, **Department of Radiology, ***The First Department of Physiology, Kansai Medical University, ****Nihon Medi-Physics Co., Ltd. |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 7 |
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| Page | 899-905 |
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| Year/Month | 1986/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : We evaluated the validity of a new radionuclide liver imaging method using an asialoglycoprotein (ASGP) receptor system on the cell membrane. Neoglycoprotein was labeled with 99mTc using SnCl2 as a reductant and administered into normal rats and those with 3'-metyl-4-dimethylaminoazobenzene induced liver cancer. This protein is physiologically equivalent to ASGP and thus binds to ASGP receptors, and is taken up by the liver. In the normal rats, liver images obtained with this new method were as clear as those obtained with 99mTc-Sn colloid. In the rats with liver cancer, lesions (10 mm in diameter) were visualized as accumulated defects showing a distinct contrast to the surrounding tissues. These defects were consistent with the macroscopic observations, and also were supported by the absence of ASGP receptor activity in lesions confirmed by measurements in cancerous and non-cancerous areas. The results indicate the usefulness of labeled neoglycoprotein as radiopharmaceutical for liver RI imaging. |
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| Practice | Clinical medicine |
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| Keywords | A sialoglycoprotein, Asialoglycoprotein receptor, Neoglycoprotein, Liver scintigram. |
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