| Japanese |
|---|
| Title | Non-specific cross-reacting antigen (NCA)-Radioimmunoassayの基礎的, 臨床的検討 |
|---|
| Subtitle | 《原著》 |
|---|
| Authors | 浦恭章*, 越智幸男*, 浜津尚就**, 石田正夫***, 梶田芳弘***, 中嶋良行*** |
|---|
| Authors(kana) | |
|---|
| Organization | *滋賀医科大学検査部, **放射線部, ***南丹病院内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 23 |
|---|
| Number | 7 |
|---|
| Page | 877-885 |
|---|
| Year/Month | 1986/7 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」: 精製NCAとNCA特異抗体を用いて, Polyethylene Glycol (PEG) 法によるNCA-RIAを確立した. 正常人および各種疾患患者の血漿NCA値を測定し, Roche CEA-RIA法によるCEA測定法と比較検討した. 正常人の血漿NCA値は105±45 ng/ml (mean±S.D.) であり, 200 ng/ml以下を正常範囲とした. 悪性腫瘍では, CEA陽性率は72%, NCA陽性率は17%であった. 悪性疾患の肝転移例では高率かつ高値 (1,000ng/ml以上) のNCA陽性例が認められた. 悪性疾患ではNCAとCEAの相関は相関係数r=0.446 (P<0.001) を認めた. 悪性疾患でNCAとCEAとも高値例が認められたが, NCA高値でCEA低値例が認められないことおよび悪性疾患でのNCA陽性率の低さより, NCAはCEAほど有用な腫瘍マーカーではないと推定された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | CEA-, NCA-Radioimmunoassay, Tumor marker. |
|---|
| English |
|---|
| Title | Fundamental and Clinical Evaluation of Radioimmunoassay (RIA) for Non-specific Cross-reacting Antigen (NCA) |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Yasuaki URA*, Yukio OCHI*, Masanari HAMAZU**, Masao ISHIDA***, Yoshihiro KAJITA***, Yoshiyuki NAKAJIMA*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Central Clinical Laboratory, **Department of Radiology, Shiga University of Medical Science, ***Nantan General Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 23 |
|---|
| Number | 7 |
|---|
| Page | 877-885 |
|---|
| Year/Month | 1986/7 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] : NCA-RIA by PEG (polyethyleneglycol) method was established using purified NCA and the specific antibody for NCA. NCA preparation (Mr ; 60,000) purified from colon cancer and anti-NCA absorbed with the purified CEA preparation were used. CEA was determined by Roche CEA-RIA kit. Plasma NCA value of 39 normal subjects was 105+-45ng/ml (mean+-S.D.) , and normal range was under 200 ng/ml. Positive ratio of CEA and NCA was 50% and 3% respectively in benign diseases (70 cases) , and 72% and 17% respectively in malignant diseases (290 cases) . Many cases of malignant diseases with liver metastasis showed high NCA levels (>1,000 ng/ml) . A correlation coefficient of r=0.446 was noted between CEA and NCA in cancer patients. NCA was less useful than CEA as tumor marker, although some cases among cancer patients showed increased NCA accompanied by increased CEA. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | CEA-, NCA-Radioimmunoassay, Tumor marker. |
|---|