| Japanese |
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| Title | 脳腫瘍患者における123I-IMP SPECT - 133Xe吸入法およびX線CTとの比較 - |
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| Subtitle | 《原著》 |
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| Authors | 陣之内正史*, 星博昭*, 渡辺克司*, 原田邦子*, 尾上耕治*, 上田孝**, 木下和夫**, 山岡信行*** |
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| Authors(kana) | |
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| Organization | *宮崎医科大学放射線科, **脳神経外科, ***島津製作所医用技術部 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 7 |
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| Page | 869-876 |
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| Year/Month | 1986/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」: 脳腫瘍患者20例に対して123I-IMPによるSPECTを施行し, 133Xe吸入法による局所脳血流 (rCBF) 像およびX線CTとの比較を行った. 装置は, リング型ECT装置SET-020 (島津製作所) で, データ収集, 処理はミニコンピュータシステムECLIPSE S-120 (日本データジェネラル) を用いた. IMP SPECTは, 10分間の閉眼安静後, IMP 1 mCiを静注し, 20分後より1,000kカウントでデータ収集した. 得られたIMP SPECT像, および133XeのrCBF像でみられる脳血流障害範囲を, X線CT上の腫瘍および周辺浮腫の範囲と比較した. 次に, 腫瘍部分のIMP取り込みの指標として, T/N比 (腫瘍および対側の皮質に相当する部分のカウント数の比) を算出した. また, 133XeによるrCBF像上でも同様にしてT/N比を算出して比較した. 転移性脳腫瘍の4例, low grade astrocytomaの6例, high grade astrocytomaの2例では, X線CT上の腫瘍と周辺浮腫まで含めた範囲に, IMP SPECTと133XeによるrCBF像の両者で血流欠損を認めた. 髄膜腫の1例では, IMP SPECTでは周辺浮腫の範囲まで欠損, 133XeのrCBF像では腫瘍の部分の血流増加と浮腫の部分の血流低下を示した. 松果体腫瘍の3例のうち1例と, 下垂体腫瘍の3例では, IMP SPECT, 133XeのrCBF像ともに欠損像はみられなかった. 腫瘍部分のIMPの取り込みの程度を示すT/N比は, 44〜96%と腫瘍の種類により若干の差がみられた. 133XeのrCBF像で求めたT/N比と比較すると, 髄膜腫を除いてr=0.76と中程度の相関を示していた. 髄膜腫の例では, IMP SPECTにて低値を, 133XeのrCBF像にて高値を示し, イメージ上のdefect, hotに相当していた. IMPのSPECTを脳腫瘍例について検討し, 臨床的には腫瘍周囲の血流動態に関する情報が得られ有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, SPECT, Brain tumor, 133Xe inhalation method, X-ray computed tomography. |
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| English |
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| Title | 123I-IMP SPECT in Patients with Brain Tumor - A Comparison with 133Xe Inhalation Method and X-CT - |
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| Subtitle | Original Articles |
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| Authors | Seishi JINNOUCHI*, Hiroaki HOSHI*, Katsushi WATANABE*, Kuniko HARADA*, Kouji ONOE*, Takashi UEDA**, Kazuo KINOSHITA**, Nobuyuki YAMAOKA*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurosurgery, Miyazaki Medical College, ***Simadzu Corporation |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 7 |
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| Page | 869-876 |
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| Year/Month | 1986/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : 123I-IMP SPECT was studied in 20 patients with brain tumor (metastasis, 4 ; low grade astrocytoma, 6 ; high grade astrocytoma, 3 ; pineal tumor, 3 ; pituitary tumor, 3 ; meningioma, 1) . Each case was intravenously injected 1 mCi of IMP. SPECT data were collected for 1,000 k counts 20 min. after injection, using a circular detector array emission tomograph system (SET 020, Shimadzu and ECLIPSE S-120, Japan Datageneral) . Low activity areas on IMP SPECT image was observed in the area of the tumor and its surrounding edema in 13 cases with metastasis, astrocytoma, and meningioma. In 3 cases with pituitary adenoma and 1 case with pineal tumor, no defect was observed. In 2 cases with pineal tumor, low activity areas were observed in the limited area of tumor. T/N ratio (activity ratio of diseased area to the opposite normal area) was calculated in each case. T/N ratios were ranged from 44% to 96%, and had no tumor specificity. Moderate correlation was observed between T/N ratios of IMP and those of rCBF obtained by 133Xe inhalation method in 18 cases without meningioma (r=0.76) . In a case with meningioma, the discrepancy of T/N ratio between IMP and 133Xe was observed, which showed high rCBF and low activity on IMP image. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, SPECT, Brain tumor, 133Xe inhalation method, X-ray computed tomography. |
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