| Japanese |
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| Title | 脳腫瘍における18FDGモデル速度定数の算出とその意義 |
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| Subtitle | 研究速報 |
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| Authors | 山口龍生*,†, 佐々木広*, 上村和夫*, 宍戸文男*, 犬上篤*, 小川敏英*, 日向野修一*, 峯浦一喜**, 菅野巖*, 村上松太郎* |
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| Authors(kana) | |
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| Organization | *秋田県立脳血管研究センター放射線医学研究部, **秋田大学医学部脳神経外科教室, †現:東北大学抗酸菌病研究所放射線医学研究部門 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 6 |
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| Page | 829-832 |
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| Year/Month | 1986/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」18F-labelled 2-fluoro-2-deoxy-D-glucose(18FDG)を用いたpositron emission tomography(PET)は, 局所ブドウ糖消費量(regional metabolic rate of glucose, rMRGlc)が神経膠腫(glioma)の悪性度と関連することから, 腫瘍イメージングの一つの有用な手法として知られている. しかし, 従来の18FDG-PETによるrMRGlc画像は, 18FDGモデルにおける速度定数が正常組織と腫瘍組織とで等しいという仮定に基づいて求められている. 速度定数, すなわちFDGの脳血液関門透過性を示すk*1, k*2とFDGの燐酸化速度を示すk*3, k*4は, 実際, 異常組織ではそれぞれ異なった値をとる. 特にk*3の値はhexokinaseの活性を表わし, rMRGlcと同様に腫瘍の悪性度との相関が考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission tomography, [18F] fluorodeoxyglucose method, Regional rate constants, Glucose consumption, Brain tumor. |
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| English |
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| Title | An Analysis of 18FDG Kinetic Rate Constants Using Dynamic Positron Emission Tomography in Human Brian Tumors |
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| Subtitle | Rapid Communication |
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| Authors | Tatsuo YAMAGUCHI*, Hiroshi SASAKI*, Kazuo UEMURA*, Fumio SHISHIDO*, Atsushi INUGAMI*, Toshihide OGAWA*, Shuichi HIGANO*, Katsuyoshi MINEURA**, Iwao KANNO*, Matsutaro MURAKAMI* |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, **Department of Neurosurgery, School of Medicine, Akita University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 6 |
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| Page | 829-832 |
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| Year/Month | 1986/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Using dynamic positron emission tomographic (PET) scans, the values of kinetic rate constants in the [18F] fluorodeoxyglucose (18FDG) model were measured in tumor tissues in 20 patients with brain tumors (total;27 examinations). The subjects consisted of 15 cases with supratentrial gliomas and 5 cases with non-glial brain tumors. Glucose metabolic rate was also calculated from individual kinetic rate constants in the tumor tissue. In respect to histologic diagnosis, all rate constants were higher on the average in the glioma grade IV and the non-glial tumor groups than in the glioma grade II and III groups. Especially, the k*3, representing hexokinase activity for 18FDG, showed high value and wide deviation in the glioma grade IV. Discrepancy was found between k*3 and the estimated glucose comsumption values in several cases with either malignant or benign cerebral tumor. Analysis of the kinetic rate constants using 18FDG-PET dynamic scanning might be quite useful for interpreting tumor nature and predicting malignancy in combination with evaluation of glucose consumption. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission tomography, [18F] fluorodeoxyglucose method, Regional rate constants, Glucose consumption, Brain tumor. |
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