| Japanese |
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| Title | In vivo NMRによる加齢に関する研究 |
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| Subtitle | 短報 |
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| Authors | 池平博夫*, 福田信男*, 山根昭子*, 篠遠仁*, 遠藤真広*, 松本徹*, 飯沼武*, 舘野之男* |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 6 |
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| Page | 825-828 |
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| Year/Month | 1986/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」加齢(老化)現象とは発生に始まり, 成育, 成熟, 老化そして死に至る一連の最も基本的な生物現象として捉えることができる. しかしこの一連の現象を制御する因子は, 今日なお確認されていない. われわれは加齢を一つの現象として, 生物の外的観察などによって認識しうるのみである. さて生物は生命活動期間において, 体内環境の恒常性が維持されているので, 生体組織の構成が極端に変化することは, 通常の生理的条件下ではほとんど考えられない. しかもヒトの場合には, 各個体についてその生涯を通じて同一の測定手段によって, 加齢現象に伴う生体組織の化学構成などの変化を追跡することは不可能である. したがって, 広い年齢範囲にわたる多数の個体の測定により加齢と生体組織の関連を検討するしかないが, この場合には測定精度を含めた各個体ごとのバラツキを超えて変化するものでないと, 加齢による変化の傾向をさえも捉えることができないことになる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Magnetic resonance, Tissue characterization, Aging study. |
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| English |
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| Title | Statistical Aging Study on the Human Tissue with In Vivo NMR |
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| Subtitle | Short Communication |
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| Authors | Hiroo IKEHIRA, Nobuo FUKUDA, Teruko YAMANE, Hitoshi SHINOTOH, Masahiro ENDO, Toru MATUMOTO, Takeshi IINUMA, Yukio TATENO |
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| Authors(kana) | |
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| Organization | Division of Clinical Research, National Institute of Radiological Science |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 6 |
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| Page | 825-828 |
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| Year/Month | 1986/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We evaluated the possibility to detect the statistical difference of each tissue's longitudinal relaxation time (T1) or longitudinal relaxation rate (R1) values, which depends on age and sex. Normal tissues of 440 peoples were studied. T1 or R1 values were gotten in each tissue with calculated T1 (Tr=1,000 msec, Td=300 msec) image, and then the regression analysis and also the statistical analysis about the correlation coefficient between T1 or R1 values and age, as well as between male and female were done. An NMR imaging system with resistive type scanner (0.1 Tesla, Asahi Mark-J) was utilized. There was not any statistical difference between each sex, but some tissues had statistically meaning correlation with age. Representative results are shown in Table 1 and Table 2. Especially, vertebral bone marrow had a typical correlation coefficient and regression coefficient. On the other hand, the long bone bone marrow and skeletal muscle showed significant correlation coefficient with those under twenty years, the so called growing age. T1 and R1 values mainly depend on the free and bound water concentration ratio. These data showed that T1 and R1 values will be possible to use as the clinical parameter of the change of the fat and free water concentration ratio in the tissue. |
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| Practice | Clinical medicine |
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| Keywords | Magnetic resonance, Tissue characterization, Aging study. |
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