| Japanese |
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| Title | 腎摂取率法を用いたGFR, ERPF, FF算出による分腎機能評価 |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 高山輝彦*, 中嶋憲一*, 山田典央*, 瀬戸幹人*, 利波紀久*, 久田欣一*, 山田正人**, 飯田泰治**, 河村昌明**, 松平正道**, 宮崎吉春*** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室, **付属病院アイソトープ部, ***能登総合病院アイソトープ部 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 6 |
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| Page | 783-791 |
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| Year/Month | 1986/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Tc-99m DTPAおよびI-131 hippuran投与後の初期腎摂取率値を, Gates法, Schlegel法に準じて求めた. 得られたTc-99m DTPA, I-131 hippuran腎摂取率値は, チオ硫酸ナトリウム・クリアランス値(r=0.910), パラアミノ馬尿酸クリアランス値(r=0.867)と, それぞれ良好な相関を示した. これらの相関結果から得られた回帰式より, 左右総腎および分腎GFR, ERPF値を算出し, さらにFF値を求めた. 正常腎機能例では, 右腎のGFR, ERPF, FF値は, 50.0±9.5ml/min, 209.1±33.8ml/min, 0.241±0.037, 左腎のGFR, ERPF, FF値は, 52.8±10.5ml/min, 214.2±42.3ml/min, 0.248±0.034を示した. さらに偏側性腎疾患である閉塞性尿路疾患と腎血管性高血圧では, 患側部のGFRとERPFは一様に変化し, GFRとERPF間で解離が見られなかったが, 腎血管性高血圧患者のPTA施行後では, GFRの改善度とERPFの改善度間で解離が見られた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Glomerular filtration rate, Effective renal plasma flow, Split renal function, Renal uptake, Unilateral renal disease. |
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| English |
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| Title | Measurement of Split Glomerular Filtration Rate, Effective Renal Plasma Flow, Filtration Fraction by Fractional Renal Uptake |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO*, Teruhiko TAKAYAMA*, Kenichi NAKAJIMA*, Norihisa YAMADA*, Mikito SETO*, Norihisa TONAMI*, Kinichi HISADA*, Masato YAMADA**, Yasuharu IIDA**, Masaaki KAWAMURA**, Masamichi MATSUDAIRA**, Yoshiharu MIYAZAKI*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, School of Medicine, Kanazawa University, **Division of Radioisotope Service, Kanazawa University Hospital, ***Division of Radioisotope Service, Noto General Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 6 |
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| Page | 783-791 |
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| Year/Month | 1986/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The total and split glomerular filtration rate (GFR) was calculated from the previously reported formula of linear regression analysis between the renal uptake of Tc-99m DTPA within 2 to 3 minutes following the radionuclide appearance into the kidneys and sodium thiosulfate clearance, accordingly: GFR(ml/min)=8.775×(% total renal uptake)+9.685. On the other hand, the total and split effective renal plasma flow (ERPF) was also determined by the modified Schlegel's method of fractional renal uptake of intravenously administered I-131 hippuran within 1 to 2 minutes following radionuclide appearance into the kidneys. After correcting the obtained renal uptake by depth and dose, the ERPF was computed from the significant correlation with paraaminohippuric acid (PAH) clearance (r=0.867, ERPF=17.2×(% total renal uptake)+49.7). And the total and split filtration fraction (FF) was determined by dividing the GFR with Tc-99m DTPA by the ERPF with I-131 hippuran. In the 24 patients without functional impairement of kidney, the split GFR, ERPF and FF of right kidney were 50.9+-9.5ml/min, 209.1+-33.8ml/min and 0.241+-0.037, and those of left kidney were 52.8+-10.5ml/min, 214.2+-42.3ml/min and 0.248+-0.034. In unilateral renal disease of 14 patients with obstructive uropathy and 9 patients with renovascular hypertension, the FF of the affected side did not show any significant changes compared to that of the unaffected side, and the alterations of GFR were well accorded with those of ERPF. Among three patients following the treatment of percutaneous transluminal angioplasty, however, some disparities between GFR and ERPF alterations were found in the affected side. |
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| Practice | Clinical medicine |
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| Keywords | Glomerular filtration rate, Effective renal plasma flow, Split renal function, Renal uptake, Unilateral renal disease. |
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