| Japanese |
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| Title | 201Tl心筋Emission CTによる各種筋ジストロフィ症患者の心筋線維化病変の評価 |
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| Subtitle | 原著 |
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| Authors | 山本秀平*, 外畑巌*, 印東利勝**, 松岡幸彦**, 河合直樹*, 松島英夫*, 鈴木晃夫*, 安部哲太郎***, 佐久間貞行*** |
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| Organization | *名古屋大学医学部第一内科, **神経内科, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 6 |
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| Page | 773-782 |
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| Year/Month | 1986/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」デュシャンヌ型, 肢帯型, 筋緊張性, 顔面肩甲上腕型, 計47例の各種筋ジストロフィ症を対象として201Tl心筋Emission Computed Tomography(ECT)を施行し, 左室5区画における灌流欠損の有無, 左室線維化率, 201Tl肺摂取率を検討した. ECT灌流欠損はデュシャンヌ型29例中, 26例および他の3病型18例中, 11例にみられ, 全体では37例(79%)の95区画(40%)にみられた. デュシャンヌ型では心尖部と後壁の灌流欠損出現頻度が高く(おのおの62%, 83%), 他の病型では灌流欠損は左室壁に均等に分布した(20〜43%). 201Tl肺摂取率は左室線維化率と有意に相関し(r=0.82, p<0.01), デュシャンヌ型(0.67±0.36)が筋緊張性ジストロフィ症(0.34±0.25)に比し有意に高値を示した. 年齢, 骨格筋障害度と左室線維化率の間には相関がみられなかった. ECTにより心拡大(7例), 心室瘤(5例), 心軸異常(23例)も高率に診断された. 201Tl心筋ECTは筋ジストロフィ症の心筋線維化病変の評価に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Muscular dystrophy, Myocardial fibrosis, Thallium-201, Myocardial emission computed tomography. |
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| English |
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| Title | Evaluation of Myocardial Involvement in Muscular Dystrophy with Thallium-201 Emission Computed Tomography |
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| Subtitle | Original Articles |
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| Authors | Shuhei YAMAMOTO*, Iwao SOTOBATA*, Toshikatsu INDO**, Yukihiko MATSUOKA**, Naoki KAWAI*, Hideo MATSUSHIMA*, Akio SUZUKI*, Tetsutaro ABE***, Sadayuki SAKUMA*** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, **Department of Neurology, ***Department of Radiology, Nagoya University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 6 |
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| Page | 773-782 |
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| Year/Month | 1986/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The clinical usefulness of thallium-201 myocardial perfusion scanning with emission computed tomography (ECT) for evaluation of left ventricular myocardial fibrosis was assessed on 47 patients with Duchenne (DMD), facioscapulohumeral (FSH), limb-girdle (LG) and myotonic (MT) dystrophy. Trans-, long- and short-axial images were interpreted quantitatively by circumferential profile analysis, and the fibrotic tissue size (%FIB) was estimated by integration of hypoperfused areas in 6 to 8 consecutive short-axial slices. Lung/mediastinum count ratios (L/M ratio), LV cavity dilatation, aneurysm formation and cardiac malrotations were also assessed with ECT. Distinct ECT perfusion defect was observed in 26 of 29 DMDs, and in 11 of 18 patients with other types. Perfusion defect was demonstrated in 95 of total 235 segments, and was observed specifically in the posterior wall (82%) and the apex (65%) in DMD, and was scattered in all LV wall segments in FSH, LG, and MT. Percent FIB correlated significantly with L/M ratio (r=0.82, p<0.01), and did not with age or clinical stage score. ECT showed marked LV dilatation in 7, apical aneurysm in 5 and cardiac malrotation in 23 of the 47 patients. In conclusion, ECT was considered to be a useful clinical means of evaluating myocardial involvement in patients with muscular dystrophy. |
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| Practice | Clinical medicine |
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| Keywords | Muscular dystrophy, Myocardial fibrosis, Thallium-201, Myocardial emission computed tomography. |
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