| Japanese |
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| Title | 201Tl全身シンチグラフィによる各種神経疾患の骨格筋病変の評価 |
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| Subtitle | 原著 |
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| Authors | 山本秀平*, 外畑巌*, 印東利勝**, 松岡幸彦**, 松島英夫*, 鈴木晃夫*, 安部哲太郎***, 佐久間貞行*** |
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| Organization | *名古屋大学医学部第一内科, **神経内科, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 6 |
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| Page | 765-771 |
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| Year/Month | 1986/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」各種神経疾患29例および正常14例を対象として201Tl全身シンチグラフィを施行し, 四肢の骨格筋病変の有無を評価した. 201Tl Cl 2mCiを静注後, 大型角形対向ディジタルガンマカメラを用いて全身をスキャンし, 201Tl全身像を得, 上腕, 前腕, 大腿および下腿における201Tl摂取低下の相対的定量判定(各関心領域カウントによる遠位・近位差, 左右差)および視覚判定を行った. 正常例では全例とも四肢骨格筋レリーフ像が得られ, 神経疾患例では筋電図, 筋生検, 理学所見等の異常がみられた170部位中, 124部位(73%)で201Tl摂取が低下した. 201Tl全身像の四肢骨格筋障害診断能は感度が72%, 特異度が78%, 正診率が76%であった. 上腕では感度, 特異度, 正診率ともに4部位中, 最も低かった. 201Tl全身シンチグラフィは各種神経疾患における骨格筋病変の分布の判定に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium-201, Whole body scintigraphy, Skeletal muscular involvement. |
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| English |
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| Title | Evaluation of Skeletal Muscular Involvement in Neuromuscular Disorders with Thallium-201 Whole Body Scintigraphy |
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| Subtitle | Original Articles |
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| Authors | Shuhei YAMAMOTO*, Iwao SOTOBATA*, Toshikatsu INDO**, Yukihiko MATSUOKA**, Hideo MATSUSHIMA*, Akio SUZUKI*, Tetsutaro ABE***, Sadayuki SAKUMA*** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, **Department of Neurology, ***Department of Radiology, Nagoya University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 6 |
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| Page | 765-771 |
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| Year/Month | 1986/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The extent as well as severity of pathologic changes of skeletal muscles were analyzed with thallium-201 whole body scintigraphy (WBS) in 29 cases of various types of neuromuscular diseases (18 cases of myogenic and 11 cases of neurogenic muscular diseases) and 14 cases of normal controls. After intravenous injection of 2 mCi of thallium-201 chloride, WBS was performed for 15 minutes using a gamma camera with twin-opposed large rectangular detectors. Counts at brachia, forearms, thighs, and calves were assessed after reconstruction of the scintigram of the whole body by taking the geometric mean of the anterior and posterior data. WBS showed uniform tracer activities in the 4 extremities in 12 cases among 14 controls. Laterality in distribution of counts of both legs and arms was noted in the remaining 2 controls. WBS revealed decrease of perfusion in the extremities with muscular atrophy and/or weakness in neuromuscular diseases. The overall diagnostic accuracy of WBS for evaluation of skeletal muscle involvement was 75 to 80% except for the bilateral brachia for which it decreased to 65%. All of the three cases of muscular dystrophy with pseudohypertrophy of the calves or thighs showed unequivocal decrease of perfusion of those regions in WBS. In conclusion, thallium-201 WBS was considered to be a useful clinical means in evaluating the extent and severity of muscular involvement of various types of neuromuscular disorders. |
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| Practice | Clinical medicine |
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| Keywords | Thallium-201, Whole body scintigraphy, Skeletal muscular involvement. |
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