Japanese
Title67Gaシンチグラフィにおける肝不描出症例についての臨床的検討
Subtitle原著
Authors篠塚明*, 広野良定*, 武中泰樹*, 神垣郁夫*, 伊藤真一*, 菱田豊彦*
Authors(kana)
Organization*昭和大学医学部放射線医学教室
Journal核医学
Volume23
Number4
Page375-388
Year/Month1986/4
Article原著
Publisher日本核医学会
Abstract「要旨」過去3年10か月間に3,129件の67Gaシンチグラフィを施行し95件(86症例)に肝不描出例を経験した. そのうち検査当日に血液検査を施行し得た77件(74症例)について肝不描出の原因を検討した. 疾患別では悪性腫瘍が58例と大部分を占め, 次いで肝硬変が10例みられた. 60件(57症例)までがUIBCが著明に低下しており, 血清トランスフェリンの飽和状態による67Gaの血中クリアランスの亢進による肝臓への取り込み低下が肝不描出の主要原因と考えられた. 悪性腫瘍や肝硬変ではUIBCが著明に低下していることが多いので肝不描出が起こりやすく, 強力な抗腫瘍剤投与はUIBCの低下をさらに助長すると思われる. UIBC低下のない例では12件(12例)に腫瘍への著明な異常集積がみられ, それによる肝臓への取り込み不足が肝不描出の原因と考えられた. しかし残りの6件(6例)についてはUIBCの低下も著明な異常集積もなく, 肝不描出の原因は不明であった.
Practice臨床医学：一般
Keywords67Ga scintigraphy, Absent liver uptake, Serum iron, TIBC, UIBC.
English
TitleStudy on Absent Liver Uptake in 67Ga Scintigraphy
SubtitleOriginal Articles
AuthorsAkira SHINOTSUKA, Yoshisada HIRONO, Hiroki TAKENAKA, Ikuo KAMIGAKI, Shinichi ITO, Toyohiko HISHIDA
Authors(kana)
OrganizationDepartment of Radiology, School of Medicine, Showa University
JournalThe Japanese Journal of nuclear medicine
Volume23
Number4
Page375-388
Year/Month1986/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractDuring the past 3 years and 10 months, we have performed 3,129 studies of 67Ga scintigraphy and 95 studies (86 cases) of these showed absent liver uptake. We investigated the cause of absent liver uptake in 77 studies (74 cases) of these 95 whose labolatory data were obtained on the day of the examination. Fifty-eight cases had malignant tumors and 10 cases had liver cirrhosis. There was no correlation between liver dysfunction and absent liver uptake. In 60 studies (57 cases), serum unsaturated ironbinding capacity (UIBC) was markedly decreased. This suggested that saturation of serum transferrin by iron was a main cause of absent liver uptake and it induced to enhance blood clearance of 67Ga and to decrease liver uptake of 67Ga. In general, many cases with malignant tumor and liver cirrhosis show decreased UIBC. And the strong treatment with anti-neoplastic agents further makes to decrease UIBC. In 12 studies (12 cases) with normal UIBC, it was suggested that marked abnormal accumulation in the tumor brought about lack of liver uptake of 67Ga. In remnant 6 studies (6 cases) with normal UIBC and no abnormal accumulation, however, the cause of absent liver uptake could not be found.
PracticeClinical medicine
Keywords67Ga scintigraphy, Absent liver uptake, Serum iron, TIBC, UIBC.

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