Japanese
Title注射用 [酸素-15] 標識水の直接製造法の検討
Subtitle原著
Authors羽上栄一*, 村上松太郎*, 高橋和弘*, 菅野巖*, 相沢康夫*, 蜂谷武憲*, 庄司安明*, 宍戸文男*, 上村和夫*
Authors(kana)
Organization*秋田県立脳血管研究センター放射線科
Journal核医学
Volume23
Number4
Page351-358
Year/Month1986/4
Article原著
Publisher日本核医学会
Abstract「要旨」H215Oをターゲットボックス内で合成する直接法の詳細を検討した. 0.1% H2を含むN2ガスを容積177mlのターゲットボックスに3.5kg/cm2充填し, 6.4MeVの重陽子で数分間バッチ法で照射した. 合成されたガス状のH215OはHeを用い, 2.5l/minでテフロン管を通じPET室に搬送し, 生理食塩水10mlを入れたバイアルに捕集し, メンブレンフィルターを通し注射液とした. ターゲットガスのH2濃度を0.1〜4.0%と変えるとNH4+濃度は25〜11,000μg/dlと変化し, 0.5%以上にするとヒト血中濃度より高濃度となったので, 0.1%H2を含むN2ガスをターゲットとした. H215Oの回収率は7mCi/μAでこれの約10％の放射能を持つC15O, C15O2, N215Oが捕集されずに後方へ抜けた. H215Oを含む生理食塩水の化学, 放射化学, 生物学的な純度はいずれも良好で臨床使用に耐え得る. 本法は簡便で安全にPET室で捕集でき, 臨床的にも有用な製造法と考える.
Practice臨床医学：一般
Keywords[O-15]-H2O, In target box synthesis, NH4+, H2 concentration, CBF.
English
TitleStudies on the Direct Synthesis of [O-15]-H2O
SubtitleOriginal Articles
AuthorsEiichi HAGAMI, Matsutaro MURAKAMI, Kazuhiro TAKAHASHI, Iwao KANNO, Yasuo AIZAWA, Takenori HACHIYA, Yasuaki SHOJI, Fumio SHISHIDO, Kazuo UEMURA
Authors(kana)
OrganizationDepartment of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels
JournalThe Japanese Journal of nuclear medicine
Volume23
Number4
Page351-358
Year/Month1986/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractA direct [O-15]-H2O synthesis method and its critical point of non-radioactive NH4+ contamination were described. The 6.4 MeV deuterons were irradiated into the target chamber of 177ml, filled up with 3.5kg/cm2 of 0.1% H2 in N2-[O-15]-H2O vapor was transported to PET room by He flow of 2.5l/min through the teflon(R) tubing of 2mm in internal diameter and of 30m in length. [O-15]-H2O was trapped in the vial containing 10ml of saline and passed through Millipore(R) filter. In this condition, the small amount of non-radioactive NH4+ (24.9+-12.8(1SD)μg/dl, n=23) was detected. This NH4+ concentration varied from 25 to 11,000μg/dl with changing H2 amount in the target from 0.1 to 4.0%. The NH4+ concentration was kept lower than a normal range of the healthy human blood with 0.5% or less H2 in N2 in the target. Therefore, 0.1% of H2 was used in clinical use. By the present method, a yield of approximately 7 mCi/μA of [O-15]-H2O saline was obtained. About 10% of radioactive gases, corresponding to C15O, C15O2 and N215O, were detected in the waste gas. The radiochemical and radionuclidic impurity was not detected in the saline. The biological tests for bacteria and pyrogen were all passed. In conclusion, the direct synthesis method provides [O-15]-H2O saline in the PET room with the simple handling and is convenient for the clinical use.
PracticeClinical medicine
Keywords[O-15]-H2O, In target box synthesis, NH4+, H2 concentration, CBF.

【全文PDF】