| Japanese |
|---|
| Title | オートラジオグラフィ法によるラットの脳血流脳代謝同時測定 |
|---|
| Subtitle | 短報 |
|---|
| Authors | 隅屋寿*, 松田博史*, 関宏恭*, 石田博子*, 久田欣一*, 森厚文**, 柴和弘**, 池田清延***, 小島一彦**** |
|---|
| Authors(kana) | |
|---|
| Organization | *金沢大学医学部核医学教室, **アイソトープ総合センター, ***医学部脳神経外科学教室, ****医療技術短期大学部 |
|---|
| Journal | 核医学 |
|---|
| Volume | 23 |
|---|
| Number | 2 |
|---|
| Page | 167-172 |
|---|
| Year/Month | 1986/2 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「I. はじめに」最近局所脳血流測定用剤としてN-isopropyl-p-[123I]iodoamphetamine(以下123I-IMP)が注目されている. 123I-IMPは初回循環での脳への取り込みが高く脳組織からの洗い出しが遅いため, 静注後一定時間であればその分布は脳血流を反映している. また微小塞栓物質を注入し測定する際と同様の理論式(reference sample method)により血流絶対値を得ることができる. 一方14C-2-deoxyglucose(以下14C-DG)はグルコースと同じcarrierで血液脳関門を通過し脳組織内に取り込まれdeoxyglucose-6-phosphateとして脳内に蓄積される. またDGを用いた脳局所グルコース消費率の算出はSokoloffによって報告されている. 123Iの半減期は約13時間であり, 14Cの半減期は約5,730年である. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | N-isopropyl-p-[123I] iodoamphetamine, 14C-2-deoxyglucose, Cerebral blood flow, Cerebral glucose metabolism. |
|---|
| English |
|---|
| Title | Simultaneous Measurement of Cerebral Blood Flow and Metabolism Rats by Autoradiographic Technique |
|---|
| Subtitle | Short Communications |
|---|
| Authors | Hisashi SUMIYA*, Hiroshi MATSUDA*, Hiroyasu SEKI*, Hiroko ISHIDA*, Kinichi HISADA*, Hirofumi MORI**, Kazuhiro SHIBA**, Kiyonobu IKEDA***, Kazuhiko KOJIMA**** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Nuclear Medicine, School of Medicine, **Radioisotope Center, ***Department of Neurosurgery,****School of Paramedicine, Kanazawa University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 23 |
|---|
| Number | 2 |
|---|
| Page | 167-172 |
|---|
| Year/Month | 1986/2 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | We performed an autoradiographic technique for the simultaneous quantitative measurements of local cerebral blood flow (reference sample method) and local cerebral metabolic rate for glucose (Sokoloff's method) using N-isopropyl-p-[123I] iodoamphetamine and 14C-2-deoxyglucose, respectively. 123I is a gamma emitting isotope with a half-life of 13 hours and can be detected with adequate resolution on standard autoradiographic films. Autoradiograms were made before and after decay of 123I, 124I and 126I; the time interval between the 2 exposures and the concentrations of the 2 tracers were adjusted to avoid significant crosscontamination. In this way, film exposures were obtained which could be processed quantitatively like single tracer autoradiograms. The validity of the method for the investigation of local coupling of flow and metabolism was tested under physiological conditions and focal cerebral ischemia in rats. Coupling was observed in the entire brain in healthy rats and cortical surface and putamenal region of the brain in rats with ischemia. On the other hand, uncoupling was observed in globus pallidus and thalamus in rats with ischemia. The technique seems to be useful to assess the precise local cerebral blood flow and glucose metabolism under various conditions. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | N-isopropyl-p-[123I] iodoamphetamine, 14C-2-deoxyglucose, Cerebral blood flow, Cerebral glucose metabolism. |
|---|