| Japanese |
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| Title | 133Xe静注法脳血流測定用高感度スラントホールコリメータの開発 |
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| Subtitle | 原著 |
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| Authors | 中村幸夫*, 恵谷秀紀*, 中村雅一**, 久住佳三*, 大森英史*, 井坂吉成*, 上原章*, 木村和文*, 小池潔***, 田口正俊***, 丸山隆利*** |
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| Organization | *大阪大学医学部中央放射線部, **第一内科, ***(株)日立メディコ |
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| Journal | 核医学 |
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| Volume | 23 |
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| Number | 2 |
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| Page | 97-104 |
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| Year/Month | 1986/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」ガンマカメラを用いて133Xeによる非侵襲的脳血流測定を行うためにマルチプローブ型専用装置に匹敵する感度と分解能を有する高感度コリメータの開発を行った. すなわち, 孔の開口径を大きくするとともにコリメータ構造をスラント型とすることで, 頭部とコリメータ間を近接させ感度の上昇およびROI設定に必要な分解能を維持することを目的とした. このコリメータは鉛製で孔径7.6mm, 孔長20mm, 隔壁厚1.5mm, 孔数1,200, スラント角を30度とした. 感度は現有の高感度平行型コリメータに比べて約17倍高かった. 分解能(FWHM)はコリメータ面で20mm, 空中5cmでは35mmであった. 15例の臨床例で133Xe 10mCi静注投与下にて脳半球を9分画した各ROIでの最高値計数率は1,046〜1,745counts/5secであり, 脳血流量算出に必要とされる十分な計数率が得られた. 本コリメータを用いるとガンマカメラによる非侵襲的局所脳血流量測定が可能であり実用に供しうるものと考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Non-invasive rCBF measurement, High sensitivity slant hole collimator, Gamma camera, Xe-133 intravenous injection method. |
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| English |
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| Title | Development of High Sensitivity Slant Hole Collimator for Measurement of rCBF by Intravenous Xe-133 Injection |
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| Subtitle | Original Articles |
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| Authors | Yukio NAKAMURA*, Hideki ETANI*, Masaichi NAKAMURA**, Yoshimi KUSUMI*, Hideshi OHMORI*, Yoshinari ISAKA*, Akira UEHARA*, Kazufumi KIMURA*, Kiyoshi KOIKE***, Masatoshi TAGUCHI***, Takatoshi MARUYAMA*** |
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| Authors(kana) | |
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| Organization | *Central Clinic of Radiology, **First Department of Internal Medicine, Osaka University Medical School, ***Hitachi Medical Co. |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 23 |
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| Number | 2 |
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| Page | 97-104 |
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| Year/Month | 1986/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The major disadvantage of the gamma camera in the non-invasive measurement of regional cerebral blood flow (rCBF) with the Xe-133 washout method is the inaccurracy of the calculated values, mainly due to the low count rate, that limits the clinical usefulness. A few studies, including ours, have been reported to design a high sensitivity parallel hole collimator for this purpose. But with these parallel hole collimators, considerable space is needed between the collimator surface and the patient's head due to the air mask in the anterior view and to his shoulder in the lateral view, that results in decreases of the sensitivity and the resolution. The newly developed high sensitivity collimator, in this report, was designed as a slant hole type, which permitted closer approach to the patient's head and better results were obtained. It has 1,200 holes of 7.6mm in diameter, 20mm length, 15mm septal thickness and 30 degree of the slant angle. The count rate with the collimator was 9,700 cps for 100μCi of Xe-133, which was 17 times more sensitive than that of the ordinary high sensitivity low energy collimator supplied by the manufacturer. The values of FWHM for the collimator were 20mm at collimator surface, and 35mm at 5cm distance from the surface in air. In 15 cases with intravenous slow injection of 10 mCi of Xe-133, peak counts were 128,353+-3,496 counts/5 sec (Mean+-SD) in the hemisphere, and 1,046+-292 to 1,745+-546 counts/5 sec (Mean+-SD) in the 20×20mm regional ROIs, respectively. From these results, it is suggested that the newly developed high sensitivity slant hole collimator has sufficient sensitivity and resolution and might be widely available for the noninvasive measurement of rCBF with a gamma camera system. |
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| Practice | Clinical medicine |
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| Keywords | Non-invasive rCBF measurement, High sensitivity slant hole collimator, Gamma camera, Xe-133 intravenous injection method. |
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