Japanese
Title脳血管障害例におけるN-Isopropyl I-123 p-Iodoamphetamine (I-123 IMP) SPECT - 主としてcrossed cerebellar diaschisisについて -
Subtitle原著
Authors百瀬敏光*, 小坂昇*, 西川潤一*, 町田喜久雄*, 大嶽達*, 土屋一洋*, 町田徹*, 渡辺英寿**, 飯尾正宏*
Authors(kana)
Organization*東京大学医学部放射線医学教室, **脳神経外科学教室
Journal核医学
Volume23
Number1
Page25-34
Year/Month1986/1
Article原著
Publisher日本核医学会
Abstract「要旨」N-isopropyl I-123 p-iodoamphetamine(I-123 IMP)および検出器回転型ガンマカメラGE 400 AC/T(or A/T)を用いて各種脳血管障害患者の脳血流分布断層像を得, 各症例に対して, crossed cerebellar diaschisisの発現, 神経症状と局所I-123 IMP集積等につき検討し以下の結果を得た. (1)出現した神経症状の責任病巣の検出, 術後の血行状態の把握に有用であった. (2)脳梗塞症例でreversible crossed cerebellar diaschisisを検出し得た. (3)モヤモヤ病, AVMの破裂による脳内出血例でもcrossed cerebellar diaschisisが検出され, 脳梗塞のみでなく, 他の脳血管障害例でもremote effectが起きていることが明らかとなった. (4)この現象の発現にはI-123 IMP-SPECT上のdefectの大きさ, 部位のみでなく, 時間的要素も重要であることが示唆された. I-123 IMP-SPECTは, こうした遠隔効果(remote effect)を簡便に検出することができ, 臨床的にも有用な検査法と考えられた.
Practice臨床医学：一般
KeywordsCerebrovascular disease, Single photon emission computed tomography, Regional cerebral blood flow, N-Isopropyl I-123 p-Iodoamphetamine, Crossed cerebellar diaschisis.
English
TitleCrossed Cerebellar Diaschisis in Cerebrovascular Disease Detected by N-Isopropyl I-123 p-Iodoamphetamine (I-123 IMP) with SPECT
SubtitleOriginal Articles
AuthorsToshimitsu MOMOSE*, Noboru KOSAKA*, Junichi NISHIKAWA*, Kikuo MACHIDA*, Tohru OHTAKE*, Kazuhiro TSUCHIYA*, Tohru MACHIDA*, Eiju WATANABE**, Masahiro IIO*
Authors(kana)
Organization*Department of Radiology, **Department of Neurosurgery, Faculty of Medicine, University of Tokyo
JournalThe Japanese Journal of nuclear medicine
Volume23
Number1
Page25-34
Year/Month1986/1
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractTo evaluate the relationship between supratentorial lesion and cerebellar perfusion, twenty-four patients with a variety of cerebrovascular diseases were examined with X-ray CT and I-123 IMP-SPECT. The individual injected dosages were 3 mCi and imaging was performed 20 min after an intravenous injection using the GB 400 A/T or AC/T, a low-energy general purpose collimator, 360° rotation, giving 64 images with an average total imaging time of 32 min. A Ramp filter with additional three dimensional filtering was used for image reconstruction. The presence of cerebellar asymmetry was related to the appearance of the supratentorial lesion. Nine out of thirteen patients with cerebral infarction were observed to have cerebellar asymmetry, even though they showed normal findings of the cerebellum on X-ray CT. This is probably due to the reduced flow in the cerebellar hemisphere contralateral to the supratentorial infarction, "crossed cerebellar diaschisis". Three out of five patients with Moyamoya disease and one out of three with an A-V malformation showed cerebellar asymmetry on I-123 IMP-SPECT. In nine normal control subjects, one with multiple infarction with dementia, and one with transient ischemic attack, the cerebellum was symmetrical. Serial studies were also performed in one stroke case and the phenomenon of crossed cerebellar diaschisis disappeared over time. In cerebral infarction with this phenomenon, a large perfusion deficit area in the parietal cortex was characteristic. Our results indicate that this phenomenon might be time dependent and that the mode of onset and the location of the lesion are important in the development of this phenomenon.
PracticeClinical medicine
KeywordsCerebrovascular disease, Single photon emission computed tomography, Regional cerebral blood flow, N-Isopropyl I-123 p-Iodoamphetamine, Crossed cerebellar diaschisis.

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