| Japanese |
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| Title | 99mTc-DTPA腎摂取率法を用いたGFR測定による分腎機能評価 |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 高山輝彦*, 中嶋憲一*, 瀬戸幹人*, 利波紀久*, 久田欣一*, 山田正人**, 飯田泰治**, 河村昌明**, 松平正道**, 宮崎吉春*** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室, **附属病院アイソトープ部, ***能登総合病院アイソトープ部 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 12 |
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| Page | 1781-1787 |
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| Year/Month | 1985/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 99mTc-DTPA腎動態検査施行時に, ほぼGates法に準じて, 99mTc-DTPAの初期腎摂取率を求めた. 得られた腎摂取率値は, 24時間クレアチニン・クリアランス値 (r=0.893) , チオ硫酸ナトリウム・クリアランス値 (r=0.846) と, 良好な相関結果を示した. 一方, チオ硫酸ナトリウム・クリアランス値との相関結果より導き出された回帰式 (y=8.775x+9.685) より算出されたGFR値と, 99mTc-DTPA腎実質レノグラムパターンとの関連では, 標準型パターンで35ml/min. 以上の分腎GFR値を呈したのに対し, 機能低下型パターンで20〜35ml/min. の範囲内の分腎GFR値を, 無機能型パターンで20ml/min. 以下の分腎GFR値を呈した. 以上, 99mTc-DTPA腎摂取率によるGFR測定は, 客観的定量的分腎機能評価法として, 有効と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-DTPA, Renal uptake, GFR, Split renal function |
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| English |
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| Title | Measurement of Split Glomerular Filtration Rate by Fractional Renal Uptake of Tc-99m DTPA |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO*, Teruhiko TAKAYAMA*, Kenichi NAKAJIMA*, Mikito SETO*, Norihisa TONAMI*, Kinichi HISADA*, Masato YAMADA**, Yasuharu IIDA**, Masaaki KAWAMURA**, Masamichi MATSUDAIRA**, Yoshiharu MIYAZAKI*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, Kanazawa University, **Division of Central Radioisotope Service, Kanazawa University Hospital, ***Division of Radioisotope Service, Noto General Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 12 |
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| Page | 1781-1787 |
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| Year/Month | 1985/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The percent renal uptake of Tc-99m DTPA, within 2 to 3 minutes following the radionuclide appearance into the kidneys according to the method by Gates, was correlated well with the sodium thiosulfate clearance determination (n=75, r=0.846) as well as the 24-hour creatinine clearance determination (n=47, r=0.893) . Therefore, the formula for calculation of glomerular filtration rate (GFR) was derived from the linear regression analysis between renal uptake of Tc-99m DTPA and sodium thiosulfate clearance determination, accordingly : GFR (ml/min.) =8.775× (%total renal uptake) +9.685. In the 31 patients without nephrouropathy, the split GFR of left kidney was 53.6+-10.9ml/min. and that of right kidney was 52.0+-11.1ml/min. The radionuclide computed GFR was also examined for the evaluation of split function of renal parenchyma, in comparison with Tc-99m DTPA renogram pattern. In most cases with standard renogram pattern, the split GFR showed the values over 35ml/min. Most cases with hypofunctioning renogram pattern showed the values of split GFR within the range of 20-35ml/min. And most cases with nonfunctioning renogram pattern showed the values under 20ml/min. In the present study, the split GFR determination was found to be a useful and reliable method for the quantitative evaluation of split function of renal parenchyma. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-DTPA, Renal uptake, GFR, Split renal function |
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