| Japanese |
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| Title | 高血圧患者および正常血圧健常者における運動負荷時の腎機能低下 - 99mTc-DTPAによる検討 - |
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| Subtitle | 原著 |
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| Authors | 水入苑生*, 林郁子*, 小原武博*, 平田清文*, 山崎純一**, 高野政明***, 佐々木康人**** |
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| Authors(kana) | |
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| Organization | *東邦大学医学部腎臓学研究室, **第一内科, ***中放核医学, ****放射線科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 12 |
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| Page | 1753-1763 |
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| Year/Month | 1985/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 CloriusとSchmidlinは運動負荷によるHippurateの輸送障害は高血圧患者に特異的な現象であると報告した. この現象の確認と成因の推察のために高血圧患者, 正常血圧健常者各14名の99mTc-DTPAによる腎動態検査, 腎摂取率から求めた糸球体濾過量 (GFR) および体液性因子を安静時と運動時に検討した. 運動は高血圧患者にも健常者にもレノグラム第2相のピーク時間の延長, 第3相の指標とした10分後放射能停滞率 (10min. counts/peak counts) の増加を生じ, GFRを低下させた. また体液性因子の検討では血漿レニン活性, アルドステロン, アドレナリン, ノルアドレナリンの上昇をひきおこした. 求めた全てのデータに両群間の有意差は認められなかった. したがって99mTc-DTPAのレノグラムにより示された腎機能低下は高血圧患者に特異的なものではなく健常者にも見られる現象であり, 両者における共通のGFRや体液性因子の変化から生じている可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-DTPA, Hypertension, Exercise, Renogram, GFR |
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| English |
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| Title | Exercise Induced Renal Dysfunction Studied by 99mTc-DTPA in Hypertensives and Normotensive Controls |
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| Subtitle | Original Articles |
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| Authors | Sonoo MIZUIRI*, Ikuko HAYASHI*, Takehiro OHARA*, Kiyofumi HIRATA*, Junichi YAMAZAKI**, Masaaki TAKANO***, Yasuhito SASAKI**** |
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| Authors(kana) | |
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| Organization | *Department of Nephrology, **Department of First Internal Medicine, ***Division of Clinical Nuclear Medicine, ****Department of Radiology, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 12 |
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| Page | 1753-1763 |
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| Year/Month | 1985/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Clorius and Schmidlin reported that the disturbance of renal hippurate transport during exercise is a phenomenon specific to patients with hypertension. Our study with 99mTc-DTPA revealed that exercise induced renal dysfunction was observed not only in hypertensives (H) but also in normotensive controls (N) . 99mTc-DTPA was intravenously injected at rest and during bicycle ergometric stress to 14H and 14N in sitting position. Serial dynamic renal images were taken, of which data were simultaneously stored in a data processor for later analysis. The renogram was drawn from the ROI on each kidney. Peak time (PT) of secretory phase and radioisotope retention rate (RR) at 10 minutes were the parameters compared between rest and exercise. GFR of each kidney was calculated from % renal uptake of 99mTc-DTPA (method reported by Gates) . Blood samples were obtained at rest and at the end of exercise for the measurement of aldosterone (ALD) , plasma renin activity (PRA) and catecholamines (A, NA) . Exercise caused significant, prolongation of PT and increase in RR (10min. counts/peak counts) both in H and N. GFR (ml/min.) during exercise was lower than at rest in both H (80.7+-22.4vs. 93.8+-16.9, p<0.02) and N (84.4+-17.3vs. 102.1+-15.1, p<0.01) . ALD, PRA, A and NA were all elevated during exercise both in H and N. None of the rest-exercise differences significantly differed between H and N. Our data indicate the exercise induced renal dysfunction demonstrated by 99mTc-DTPA renograms is not specific to H but can also be observed in N, which may have resulted from changes common to H and N, as indicated by GFR and humoral factors. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-DTPA, Hypertension, Exercise, Renogram, GFR |
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