| Japanese |
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| Title | 神経芽細胞腫の診断におけるI-131meta-iodobenzylguanidineシンチグラフィの意義 |
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| Subtitle | 研究速報 |
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| Authors | 小田野幾雄*, 武田正之**, 酒井邦夫* |
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| Organization | *新潟大学医学部放射線医学教室, **泌尿器科学教室 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 11 |
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| Page | 1685-1688 |
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| Year/Month | 1985/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」 神経芽細胞腫 (neuroblastoma) は小児悪性腫瘍の中でも白血病についで多く, 本邦における発生頻度は1/4万〜1/10万といわれる. その予後はきわめて不良であるが, 早期すなわち腫瘍が限局している時期に発見できれば比較的容易に治癒させることができる. 1984年, Kimmigらは, I-131 meta-iodobenzylguanidine (以下I-131 MIBGと略す) が集積した神経芽細胞腫の一例を報告し, 本邦でも若干の集積例が発表されている. しかし, まだ症例が少なく, その臨床的意義は確立していない. 最近われわれはI-131 MIBGを入手する機会を得て, 6例の神経芽細胞腫の診断に応用し, 従来の診断法と比較しながら本腫瘍におけるI-131 MIBGシンチの診断的意義を検討することができたので, その結果を報告する. 「II. 対象と方法」 対象は神経芽細胞腫Stage I (術後) 1例, stage II (術後) 1例およびstage IV 4例の計6例である. |
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| Practice | 臨床医学：一般 |
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| Keywords | I-131 MIBG, Neuroblastoma, Urinary VMA, Pheochromocytoma, Screening method |
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| English |
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| Title | Significance of I-131 Meta-Iodobenzylguanidine Scintigraphy in Diagnosing Neuroblastoma |
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| Authors | Ikuo ODANO*, Masayuki TAKEDA**, Kunio SAKAI* |
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| Organization | *Department of Radiology, **Department of Urology, Niigata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 11 |
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| Page | 1685-1688 |
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| Year/Month | 1985/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Six patients with pathologically proved neuroblastoma (stage I, II and IV) had undergone I-131 meta-iodobenzylguanidine (MIBG) scintigraphy, which has been recently used for diagnosis of pheochromocytoma. Abnormal accumulation of I-131 MIBG was not seen in two patients with negative urinary VMA, but was observed in the remainders with positive urinary VMA. The smallest primary tumor detected on scintigram was almost 3.5cm in diameter. This scintigraphy was considered to be useful in determining the size, localization and metastasis of neuroblastoma. Because of low mechanical resolution of I-131 nuclide, however, some difficulties were noted in the differential diagnosis between tumor images and normal organ accumulation in small-sized child of neuroblastoma. |
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| Practice | Clinical medicine |
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| Keywords | I-131 MIBG, Neuroblastoma, Urinary VMA, Pheochromocytoma, Screening method |
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