| Japanese |
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| Title | 新しい放射性医薬品Tc (V) -99m Dimercaptosuccinic acidによる腫瘍シンチグラフィに関する研究 : 臨床的有用性について |
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| Subtitle | 原著 |
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| Authors | 太田仁八†,*, 遠藤啓吾*, 小泉満*, 藤田透*, 阪原晴海*, 中島鉄夫*, 鳥塚莞爾*, 幡直孝**, 枡田秀祐**, 四方田勇**, 堀内和子**, 横山陽**, 清水泰知***, 石井昌生†, 笠原勝幸**** |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, †現:神戸市立玉津病院内科, **薬学部放射性薬品化学教室, ***医学部口腔外科, ****医学部整形外科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 11 |
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| Page | 1653-1660 |
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| Year/Month | 1985/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 Tc-99mの核種としての理想的な性質に注目し, 新しい腫瘍シンチグラフィ用製剤Tc(V)-99m Dimercaptosuccinic acid (以下Tc(V)-DMS) を開発した. Tc(V)-DMSの臨床的有用性を検討するため未治療で, 病理組織診断のついた400例についてTc(V)-DMS腫瘍シンチグラフィを施行し, 一部の症例ではGa-67 citrateと比較した. Tc(V)-DMSの臨床的有用性は部位, 組織型により著しく異なり, 頭頸部腫瘍, 甲状腺髄様癌, 軟部組織腫瘍, 骨腫瘍でTc(V)-DMSシンチグラフィが有用であった. しかし, 肺腫瘍, 肝腫瘍, 悪性黒色腫, 悪性リンパ腫では無効例が多く, Ga-67 citrateの方が優れていた. Tc(V)-DMSは安価で静注後2時間以内によい画像が得られるため部位によってはTc(V)-DMS腫瘍シンチグラフィはよい適応があると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tc(V)-99m dimercaptosuccinic acid, Tumor imaging, Tc-99m labeled tumor seeking agent |
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| English |
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| Title | Tumor Imaging Using Tc(V)-99m Dimercaptosuccinic Acid, a Newly Developed Radiopharmaceutical : its Clinical Usefulness |
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| Authors | Hitoya OHTA*, Keigo ENDO*, Mitsuru KOIZUMI*, Toru FUJITA*, Harumi SAKAHARA*, Tetsuo NAKASHIMA*, Kanji TORIZUKA*, Naotaka HATA**, Hidesuke MASUDA**, Isamu YOMODA**, Kazuko HORIUCHI**, Akira YOKOYAMA**, Yasutomo SHIMIZU***, Masao ISHII†, Katsuyuki KASAHARA**** |
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| Authors(kana) | |
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| Organization | *The Department of Nuclear Medicine, †現:神戸市立玉津病院内科, **Radiopharmaceutical Sciences, Faculty of Pharmaceutical Sciences, ***Oral Surgery, ****Orthopedics, Kyoto University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 11 |
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| Page | 1653-1660 |
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| Year/Month | 1985/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Being aware of the ideal nuclear properties of Tc-99m, we have developed a new tumor seeking agent, Tc-99m (V) dimercaptosuccinic acid (Tc(V)-DMS) . In order to evaluate its clinical usefulness of Tc(V)-DMS, 400 untreated patients with histologically proven diagnoses were studied, and, in some selected cases, the results were compared with those of Ga-67 citrate. The Tc(V)-DMS scintigraphy was found especially useful in patients with head and neck tumors, medullary thyroid carcinomas, soft tissue tumors and bone tumors. But in patients with lung tumors, liver tumors, malignant melanoma or malignant lymphomas, it revealed no obvious advantage over Ga-67 scintigraphy, the results seemed to the different uptake mechanism of Tc(V)-DMS from that of Ga-67 citrate. Nevertheless the superiority of physical properties of Tc-99m, pharmacological advantage that may enable satisfactory imaging, and lower supply cost, Tc(V)-DMS would certainly offer good clinical applicability in some regions. |
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| Practice | Clinical medicine |
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| Keywords | Tc(V)-99m dimercaptosuccinic acid, Tumor imaging, Tc-99m labeled tumor seeking agent |
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