| Japanese |
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| Title | ガドリニウムDTPAによるNMR-CT腎動態機能検査 (第2報) - 局所レノグラムと非観血的GFR測定法について - |
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| Subtitle | 原著 |
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| Authors | 池平博夫*, 鳥居伸一郎*, 山根昭子*, 福田信男*, 柴田貞夫**, 遠藤真広*, 松本徹*, 篠遠仁*, 飯沼武*, 舘野之男* |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部, **化学研究部 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 11 |
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| Page | 1615-1624 |
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| Year/Month | 1985/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 Gd-DTPA (diethylenetriamin pentaacetic acid) を用いて, NMR-CTによる腎動態機能検査の評価を動物実験によって行った. Gd-DTPAの濃度変化は, T1 (300, 1000) 画像より得られた縦緩和率 (1/T1) により, Gd-DTPA静注後経時的に90分間測定した. GFR (glomeruler filtration ratio) 値は非観血的方法により, 単一コンパートメントモデルによって算出し, 局所レノグラムは腎全体, 腎皮質, 腎髄質および可能な場合には腎盂各部での縦緩和率の変化を経時的にプロットし作成した. 動物の疾患モデルとしては家兎を使用し, 尿管結紮モデル5例と腎動脈狭窄モデル3例を作成した. 測定したGFR値は対照例9例で3.7±0.9ml/minであった. NMR-CTによる腎動態機能検査は, 腎の局所動態機能を断層画像上で把握でき, 採血することなくGFR値を推定できるので有効であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | NMR-CT, Contrast agents, Gadolinium DTPA, GFR, Renogram |
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| English |
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| Title | Evaluation of the Renal Kinetic Function, Using NMR-CT by Gadolinium-DTPA (Report 2) - NMR-CT Regional Renogram and Glomeruler Filtration Ratio - |
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| Subtitle | Original Articles |
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| Authors | Hiroo IKEHIRA*, Shinichiro TORII*, Teruko YAMANE*, Nobuo FUKUDA*, Sadao SHIBATA**, Masahiro ENDO*, Toru MATUMOTO*, Hitoshi SHINOTOH*, Takeshi IINUMA*, Yukio TATENO* |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, **Division of Chemistry, National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 11 |
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| Page | 1615-1624 |
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| Year/Month | 1985/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The evaluation of the renal kinetic function in rabbits, using NMR-CT by Gd-DTPA was tried experimentally. The changes of Gd-DTPA concentration on relaxation rates (1/T1) followed continuously for 90 minuites after intravenous injection of Gd-DTPA (0.05mmol/kg) with calculated T1 (300, 1000) images. GFR (glomeruler filtration ratio) values were calculated without blood sampling, and also regional NMR-CT renography were made in the whole kidney, the renal cortex, the renal medulla and also the renal pelvis in the possible cases. Two kinds of renal dysfunction models were made, they were ureteral occlusion model in 5 rabbits and renal artery stenosed model in three rabbits. The calculated GFR value of the control rabbit was 3.7+-0.9ml/min. And the NMR-CT regional renography and GFR values were useful for the detection of the regional renal function in the NMR tomographic image. In conclusion, the NMR-CT renography using Gd-DTPA proposed useful data for regional renal kinetic study, and it will be possible to get GFR value without blood sampling. |
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| Practice | Clinical medicine |
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| Keywords | NMR-CT, Contrast agents, Gadolinium DTPA, GFR, Renogram |
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