| Japanese |
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| Title | 高血圧における拡張早期左室充満の検討 |
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| Subtitle | 原著 |
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| Authors | 成田充啓*, 栗原正*, 村野謙一*, 宇佐美暢久*, 本田稔**, 金尾啓右** |
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| Organization | *住友病院内科, **アイソトープ室 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 10 |
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| Page | 1529-1537 |
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| Year/Month | 1985/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 健常10例, 心肥大以外に合併症のない慢性高血圧 (HT) 27例を対象に99mTc心プールスキャンを施行し, HTにおける拡張期動態とそれに影響する因子を検討した. HTは心エコー図での壁肥厚の有無, 心電図左室肥大の有無より3群に区分した. また心エコー図より左室心筋重量 (LV mass) , 左室収縮期壁応力 (WS) を求めた. 健常群, HT 3群間に安静時左室収縮機能, 運動負荷に対する左室駆出率の反応に差をみなかった. 他方拡張早期左室充満を示す拡張早期1/3での左室平均充満速度 (1/3 FR mean) は, HT群で健常群より有意の低下を示し, ことに左室壁肥厚を有する群で著明であった. 1/3 FR meanと血圧, WS, 左室拡張終期容積, 左室収縮機能との間には相関をみなかったが, 1/3 FR meanとLV massとの間にはr=-0.84の高度の負の相関が存在した. 以上よりHTにおいては, 収縮機能障害や心肥大の出現する以前に拡張早期左室充満障害が出現し, その程度はLV massと関連することが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hypertension, Gated blood pool imaging, Left ventricular filling rate, Left ventricular mass |
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| English |
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| Title | Left Ventricular Diastolic Filling in Patients with Systemic Hypertension |
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| Subtitle | |
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| Authors | Michihiro NARITA*, Tadashi KURIHARA*, Kenichi MURANO*, Masahisa USAMI*, Minoru HONDA**, Keisuke KANAO** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine, Sumitomo Hospital, **Division of Nuclear Medicine, Sumitomo Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 10 |
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| Page | 1529-1537 |
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| Year/Month | 1985/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To study the prevalence and significance of left ventricular (LV) diastolic dysfunction in mild to moderate systemic hypertension (HT) , cardiac blood pool imagings with Tc-99m were obtained in 10 normal subjects and 27 patients with HT. The patients with HT did not show any evidence of coronary heart disease, renal insufficiency, cerebrovascular accident or diabetes mellitus. They were divided into 3 groups ; (1) HT-1 (n=10) : without evidence of echocardiographic (UCG) and electrocardiographic (ECG) left ventricular hypertrophy (LVH) , (2) HT-2 (n=8) : with evidence of ECG-LVH without UCG-LVH, (3) HT-3 (n=9) : with evidence of UCG-LVH. UCG-LVH was defined when posterior or interventricular septal tall thickness exceeded 13mm at end-diastole. From UCG findings LV mass was calculated and from UCG findings and auscultating brachial systolic pressure LV peak-systolic wall stress (WS) was obtained. Cardiac blood pool imagings were performed at modified LAO at rest and during exercise stress. Indices of LV systolic function (rest ejection fraction, mean ejection rate during the first third of ejection and exercise ejection fraction response) were essentially similar in normal subjects and all HT groups. In contrast, LV diastolic filling rate during the first third of diastole (1/3 FR mean) decreased significantly in any group of HT, and it was prominent in HT-3. In patients with HT, 1/3 FR mean did not correlate with blood pressure, LV peak-systolic WS, LV systolic functions and LV end-diastolic volume. But it correlated inversely with LV mass (r=-0.84) . These results suggest that impairment of early diastolic LV filling can be detected before systolic cardiac impairment and LVH develop, and it is, at least in part, relate to the LV mass. |
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| Practice | Clinical medicine |
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| Keywords | Hypertension, Gated blood pool imaging, Left ventricular filling rate, Left ventricular mass |
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