| Japanese |
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| Title | 15O標識ガスsteady state法における局所脳血流量測定の誤差の解析 |
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| Subtitle | 原著 |
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| Authors | 三浦修一*, 菅野巖*, 飯田秀博*, 村上松太郎*, 高橋和広*, 宍戸文男*, 上村和夫* |
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| Authors(kana) | |
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| Organization | *秋田県立脳血管研究センター放射線科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 10 |
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| Page | 1469-1475 |
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| Year/Month | 1985/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 局所脳血流量 (rCBF) はC15O2ガスの持続吸入とポジトロンエミッショントモグラフィ (PET) を使ったsteady state法により定量的に測定できる. しかし本法においては, PETの測定値である脳組織内15O濃度とrCBF値が非直線的な関係にあるため, rCBF値にはPET測定値の統計誤差が増幅されて含まれる. このrCBF値の誤差を簡単なファントム実験結果と動脈血中15O濃度値を用いて算出する方法とその結果を述べた. またrCBF画像の解析のときに各脳組織に設定される関心領域 (ROI) の大きさと, 得られるrCBF値の精度との関係を求めた. その結果, 7,600cps/gの平均動脈血中15O濃度で, rCBFが20から60ml/100ml脳組織/minの範囲に対し, ROI内の絵素数が300個以上のときその誤差率は1%以内であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebral blood flow, Steady state method, Positron emission tomography, Statistical accuracy |
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| English |
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| Title | Analysis of Statistical Accuracy in Regional Cerebral Blood Flow Measurement by Steady State Method |
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| Subtitle | Original Articles |
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| Authors | Shuichi MIURA, Iwao KANNO, Hidehiro IIDA, Matsutaro MURAKAMI, Kazuhiro TAKAHAsHI, Fumio SHISHIDO, Kazuo UEMURA |
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| Authors(kana) | |
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| Organization | Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 10 |
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| Page | 1469-1475 |
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| Year/Month | 1985/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Regional cerebral blood flow (rCBF) can be measured using the continuous inhalation of C15O2 and positron emission tomography (PET) . However, the determination of rCBF in the technique (steady state method) amplifies the statistical errors inherent in the transmission and emission scan of PET study. This is based on the nonlinear relation between the measured data in PET and rCBF to be calculated in the steady state model. This paper presents the method to estimate the propagation errors in rCBF using simple phantom measurements and the results obtained using the above estimation method. This estimation method makes it possible to easily apply to each cases in clinical study because of obtaining the propagation errors in rCBF with the measured value of arterial concentration of 15O of a patient. The relation between the number of pixels within region of interest (ROI) on rCBF image and the accuracy of rCBF, which is mean pixel value within the ROI, has been also examined. As the results, the errors in rCBF at arterial concentration of 7,600cps/g (mean value of our clinical studies) became less than 1% (coefficient of variation) with more than 300 pixels within ROI over the range of 20 to 60ml/100ml brain tissue/min. |
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| Practice | Clinical medicine |
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| Keywords | Cerebral blood flow, Steady state method, Positron emission tomography, Statistical accuracy |
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