| Japanese |
|---|
| Title | 11C-メチオニンによる癌と炎症の鑑別診断の基礎的研究 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 窪田和雄*, 松澤大樹*, 藤原竹彦*, 阿部由直*, 畑澤順*, 川辺弘明*, 宮沢英充*, 佐藤多智雄*, 井戸達雄**, 石渡喜一** |
|---|
| Authors(kana) | |
|---|
| Organization | *東北大学抗酸菌病研究所放射線医学部門, **東北大学サイクロトロンRIセンター |
|---|
| Journal | 核医学 |
|---|
| Volume | 22 |
|---|
| Number | 9 |
|---|
| Page | 1327-1332 |
|---|
| Year/Month | 1985/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 先にわれわれは, 11C-メチオニンがポジトロン断層による癌診断に有用であることを報告した. 本研究は11C-メチオニンの炎症への集積を調べ, 腫瘍との鑑別診断が可能か否かを明らかにするために行われた. ドンリューラット背部皮下に, クロトン油およびカラゲニンを注射して無菌性炎症を作り, 11C-メチオニンを投与し体内分布と炎症巣への集積を調べた. その結果炎症巣への集積動態は緩徐な排泄型であり, 肝, 腎, 腫瘍などに比し著明に低く, ほぼ筋肉に近い値であった. また14C-メチオニンによるマクロオートラジオグラフィーでも同様にクロトン油による炎症巣への集積はほとんどなく, 腫瘍への高い集積と比べ著明なコントラストを示した. 11C-メチオニンは炎症に集まらず, 腫瘍との鑑別診断が可能と思われた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 11C-Methionine, Tumor diagnosis, Inflammation, Rats experiment |
|---|
| English |
|---|
| Title | An Experimental Study on Differential Diagnosis of Cancer from Inflammation Using 11C-L-Methionine |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Kazuo KUBOTA*, Taiju MATSUZAWA*, Takehiko FUJIWARA*, Yoshinao ABE*, Jun HATAZAWA*, Hiroaki KAWABE*, Hidemitsu MIYAZAWA*, Tachio SATO*, Tatsuo IDO**, Kiichi ISHIWATA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Nuclear Medicine and Radiology, The Research Institute for Tuberculosis and Cancer, Tohoku University, **The Cyclotron and Radioisotope Center, Tohoku University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 22 |
|---|
| Number | 9 |
|---|
| Page | 1327-1332 |
|---|
| Year/Month | 1985/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] We have reported that 11C-L-methionine (11C-Met) was a useful labelled amino acid for the diagnosis of cancer using Positron emission computed tomography. In this report, we studied whether 11C-Met accumulated into inflammatory tissues or not for the differential diagnosis of cancer and inflammation. Aseptic inflammations on the back of Donryu rats produced by s.c. injections of croton oil or 1.5% carrageenan, showed a low level accumulation of 11C-Met as was in the muscle or blood. Time activity curves of inflammation showed clearance pattern and were significantly lower than that of pancreas, liver and cancer. Macro-autoradiographic studies 14C-Met showed the same results and hepatoma AH 109A was clearly differentiated from the inflammation induced by croton oil. It is suggested that we can differentiate cancer from inflammation with positron emission computed tomography using 11C-Met. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 11C-Methionine, Tumor diagnosis, Inflammation, Rats experiment |
|---|