| Japanese |
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| Title | ポジトロン標識アミノ酸による腫瘍診断の比較研究 |
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| Subtitle | 原著 |
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| Authors | 窪田和雄*, 松澤大樹*, 藤原竹彦*, 伊藤健吾*, 阿部由直*, 畑沢順*, 吉岡清郎*, 福田寛*, 伊藤正敏*, 佐藤多智雄*, 清澤源弘**, 井戸達雄***, 岩田錬***, 石渡喜一***, 四月朔日聖一*** |
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| Authors(kana) | |
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| Organization | *東北大学抗酸菌病研究所放射線医学部門, **医学部眼科, ***サイクロトロンRIセンター |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 7 |
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| Page | 981-987 |
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| Year/Month | 1985/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」癌のポジトロン断層診断に最も適したアミノ酸を見つけるため, ラット肝癌AH109Aへのin vivoでの取り込みを11C標識アミノ酸11種13N標識アミノ酸2種について比較した. 腫瘍集積が最も高かったのは11C-ACPC (Aminocyclopentanecarboxylic acid) で投与20分後の%投与量/gは3.46, 次は11C-L-メチオニンで2.74, ロイシン2.20の順であった. ACPCは肝に入らないという長所があるが腫瘍集積機序がよくわかっていない. 腫瘍/血液比はACPC4.63, メチオニン11.40であり, 血中のクリアランスが早いこと, 必須アミノ酸であり腫瘍のアミノ酸代謝, タンパク合成に組み込まれることを考えると, 11Cメチオニンが腫瘍のアミノ酸代謝の指標としてポジトロン断層診断用に最適であることがわかった. また, ウサギVX2腫瘍を用いて, ポジトロン断層撮影を行い, 11Cメチオニン, 11C-ACPCの両者で明瞭に腫瘍を描出できた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tumor diagnosis, 11C-and 13NAmino acids, Positron emission tomography, Rat AH109A tumor, Rabbit VX2 tumor |
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| English |
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| Title | Comparative Study of Tumor Diagnosis Using 11C-and 13N-labeled Amino Acids |
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| Subtitle | Original Articles |
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| Authors | Kazuo KUBOTA*, Taiju MATSUZAWA*, Takehiko FUJIWARA*, Kengo ITO*, Yoshinao ABE*, Jun HATAZAWA*, Seiro YOSHIOKA*, Hiroshi FUKUDA*, Masatoshi ITO*, Tachio SATO*, Motohiro KIYOSAWA**, Tatsuo IDO***, Ren IWATA***, Kiichi ISHlWATA***, Shyouichi WATANUKI*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine and Radiology, the Research Institute for Tuberculosis and Cancer, **Department of Opthalomology, School of Medicine, ***The Cyclotron and Radioisotope Center, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 7 |
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| Page | 981-987 |
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| Year/Month | 1985/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to find the most valuable 11C- or 13N-amino acid for the diagnosis of cancer using positron emission tomography, comparative studies were carried out with eleven 11C-labeled and two 13N-labeled amino acids including both essential and synthetic unphysiological amino acids. 11C-aminocyclopentanecarboxylic acid (ACPC) showed the highest uptake in the rat hepatoma AH109A (3.46%dose/g) and the second was 11C-methionine (2.74%dose/g) . 11C-ACPC characteristically showed low accumulation in liver, resulting in the high tumor/liver ratio of 2.29. 11C-methionine showed the fastest blood clearance resulting in the highest tumor/blood ratio of 11.40, although that of 11C-ACPC was 4.63. Positron emission tomography of rabbit bearing VX2 tumor showed clear tumor images by using both 11C-methionine and 11C-ACPC. 11C-methionine seemed to be incorporated into the protein metabolism of the tumor as a essential amino acid. These data suggested that 11C-methionine was one of the most useful tracer of amino acid for the diagnosis of cancer. |
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| Practice | Clinical medicine |
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| Keywords | Tumor diagnosis, 11C-and 13N-Amino acids, Positron emission tomography, Rat AH109A tumor, Rabbit VX2 tumor |
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