| Japanese |
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| Title | Single breath washout法によるfunctional image作成に適した換気の指標とmatrix sizeの検討 |
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| Subtitle | 原著 |
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| Authors | 蝦名昭男*, 井沢豊春*, 手島建夫*, 平野富男*, 今野清* |
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| Organization | *東北大学抗酸菌病研究所内科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 7 |
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| Page | 971-980 |
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| Year/Month | 1985/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」一回呼吸洗い出し法を用いて, 肺の機能図の作成に適したマトリックスの大きさと指標について検討した. 一回呼吸洗い出し法は, 133Xeを10〜15mCi吸入させた場合, バックグラウンドをほとんど考慮する必要がなかった. 洗い出し曲線から直接に求めた50%洗い出し時間 (T 1/2 R) は, 16×16マトリックスに分割した肺領域 (2.5×2.5cm) においても, 慢性閉塞性肺疾患例では求められない領域があり, T 1/2 Rを基準とする限り, さらに大きな肺領域を対象とする必要があった. 一次指数近似曲線は, 洗い出し曲線と解離し, 求めた50%洗い出し時間 (T 1/2 exp) はT 1/2 Rと相関がわるく, T 1/2 Rの代用とはならなかった. 洗い出し開始10秒後から130秒後までの洗い出し曲線の面積を10秒後と130秒後の平均カウントの差で除して求めたTA,HはT 1/2 Rとの相関もよく, 常に求められ, 一秒率などの肺機能との相関もよく, 局所肺の換気や肺機能を反映した機能図の作成に最も適していた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 133Xe, Single breath washout, Ventilation index, Matrix size, Functional image |
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| English |
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| Title | Matrix Size and Ventilation indexes for Generating Functional Images by Single-breath Washout with Xenon Gas |
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| Subtitle | Original Articles |
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| Authors | Akio EBINA, Toyoharu ISAWA, Takeo TESHIMA, Tomio HIRANO, Kiyoshi KONNO |
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| Authors(kana) | |
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| Organization | Department of Medicine, the Research Institute for Chest Diseases and Cancer, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 7 |
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| Page | 971-980 |
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| Year/Month | 1985/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to get a functional image of the lungs for estimating regional ventilation, the 133Xe ventilation studies by a single breath washin and washout with air were analyzed on 39 patients with various chest diseases and 4 normal subjects. We analyzed the washout curves on the whole and regional lungs between 10 and 75 or between 10 and 130 sec after washout started. Three different ventilation indexes were calculated ; real half time (T 1/2 R) , half time estimated from exponential curve-fitting (1/2 T exp) , and/or the area under the washout curve divided by the difference in mean count-rate between 10 and 75 or between 10 and 130 sec after washout started (TA, H) . When a single matrix was selected out of 32×32 matrixes as a region of interest in the lung, the washout curve fluctuated so much that it was difficult to get the regional T 1/2 R. In patients with good lung function and/or in the normal subjects, T 1/2 R could be estimated without difficulty even in a lung region larger than or equal to the size of a single matrix when the lungs were divided into 16×16matrixes, but in patients with COPD it could still hardly be estimated. In a single matrix out of 16×16 matrixes the correlation between T 1/2 R and TA,H become higher and the correlation between T 1/2 R and T 1/2 exp was less good as we made the interval of analysis longer. TA,H correlated better with T 1/2 R than T 1/2 exp in any interval of analysis. There was a statistically significant correlation between FEV1.0% and each of the three indexes calculated from overall lung area (r=0.8) . To make a functional image of regional ventilation by 133Xe single breath washin and washout procedure, it would be better to use the following : a) interval of analysis between 10 and 130 sec after washout started ; b) 16×16 matrix ; and c) TA,H as a ventilation index. |
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| Practice | Clinical medicine |
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| Keywords | 133Xe, Single breath washout, Ventilation index, Matrix size, Functional image |
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