| Japanese |
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| Title | シンチカメラを用いた133Xe 1回注射多段階下肢筋血流測定法 (SDMM) の開発 - 方法論と基礎的検討 - |
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| Subtitle | 原著 |
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| Authors | 分校久志*, 瀬戸幹人*, 滝淳一*, 南部一郎*, 四位例靖*, 利波紀久*, 久田欣一*, 河村昌明*, 飯田泰治**, 山田正人**, 松平正道** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室, **付属病院アイソトープ部 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 5 |
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| Page | 575-582 |
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| Year/Month | 1985/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」運動中の133Xe下肢筋血流量(MBF)測定を目的として, シンチカメラを用いた133Xe 1回注射による運動前, 中, 後の多段階下肢筋血流量測定法(SDMM)を開発し, 精度, 再現性の評価を行った. SDMMは1回の133Xe筋注後に測定した運動前後の安静時のMBFから, 各測定と運動開始, 終了との時間遅れを補正して運動中のMBFを算出する方法である. 正常有志11名を対象として, 左右下肢の4〜6筋群で測定した. 運動前後の測定は2.5分で十分であった(5分と2.5分でr=0.996). 下肢固定した足首運動時の実測MBFとSDMMによる推定MBFはよく一致した(r=0.9985). SDMMの再現性は良好であった(r=0.9996). 運動中増加したMBFは, 軽運動後は迅速に前値に戻るが, 重運動後では増加が持続した. 本法は運動前, 中, 後のMBF算出が可能であり, 虚血肢のMBF予備能の評価のみならず, 運動の内容とMBFの関係など, スポーツ医学にも応用しうるものであると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Xe-133, Muscle blood flow, Single dose multistep method, Gamma camera, Exercise. |
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| English |
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| Title | Development of a New Xe-133 Single Dose Multi-step Method (SDMM) for Muscle Blood Flow Measurement Using Gamma Camera - Methodology and Basic Evaluation - |
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| Subtitle | |
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| Authors | Hisashi BUNKO*, Mikito SETO*, Junichi TAKI*, Ichiro NANBU*, Yasushi SHIIRE*, Norihisa TONAMI*, Kinichi HISADA*, Masaaki KAWAMURA*, Taiji IIDA**, Masato YAMADA**, Masamichi MATSUDAIRA** |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 5 |
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| Page | 575-582 |
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| Year/Month | 1985/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to measure the muscle blood flow (MBF) during exercise (Ex), a new Xe-133 single dose multi-step method (SDMM) for leg MBF measurement before, during and after Ex using gamma camera was developped. Theoretically, if the activity of Xe-133 in the muscle immediately before and after Ex are known, then the mean MBF during Ex can be calculated. In SDMM, these activities are corrected through correction formula using time delays between end of data aquisition (DA) at rest (R1) and begining of the Ex (TAB), and between end of Ex and begining of the DA after Ex (R2)(TDA). Validity of the SDMM and MBF response on mild and heavy Ex were evaluated in 11 normal volunteers. Ex MBF calculated from 5 and 2.5 min DA (5 sec/frame) both at R1 and R2 were highly correlated (r=.996). Ex MBF by SDMM and direct (measurement by fixed leg exercise were also highly correlated (r=.999). Reproducibility of the R1 and Ex MBF were excellent (r=.999). The highest MBF was seen in GCM on miled walking Ex and in VLM on heavy squatting Ex. After miled Ex, MBF rapidly returned to normal. After heavy Ex, MBF remaind high in VLM In conclusion, SDMM is simple and accurate method for evaluation of dynamic MBF response according to exercise. SDMM is also applicable to the field of sports medicine. |
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| Practice | Clinical medicine |
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| Keywords | Xe-133, Muscle blood flow, Single dose multistep method, Gamma camera, Exercise. |
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