| Japanese |
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| Title | 腎細胞癌における67Ga-citrate断層シンチグラフィの意義 |
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| Subtitle | 原著 |
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| Authors | 川村寿一*, 伊藤坦*, 飛田収一*, 吉田修*, 藤田透**, 鳥塚莞爾** |
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| Organization | *京都大学医学部泌尿器科, **放射線核医学科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 4 |
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| Page | 491-499 |
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| Year/Month | 1985/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」腎細胞癌56症例に67Ga-citrate断層シンチグラフィを施行し, 患腎へのGa集積の有無と血液生化学的検査所見や予後との関係について検討した. 1. 28例にGaの取り込みを認め (Ga (+) 群) , 25例に取り込みがなく (Ga (-) 群) , 3例はGaの取り込みの有無の判定が困難であった (Ga (±) 群) . 2. Ga (+) 群の特徴としてhigh grade, high stageのものが多く, 血液生化学的検査項目のうち, 赤沈, CRP, 血清α2グロブリン, フェリチン, 銅に異常値を認めた. 3. 肺転移巣のGa陽性例は, 17例中11例 (64.7%) であったが, Ga (+) 群に限ると, 13例中11例 (84.6%) となった. 4. 予後について, Ga (+) 群は2〜60か月のfollow upで, 28例中18例 (64.3%) が死亡し, 癌なし生存7例 (25%) , 癌あり生存3例 (10.7%) , 3年生存率21.0%であった.一方, Ga (-) , (±) 群は3〜41か月のfollow upで, 28例中4例 (14.3%) が死亡し, 癌なし生存が20例 (71.4%) , 癌あり生存が4例, (14.3%) , 3年生存率78.8%はであった.このように腎細胞癌に対するGaシンチグラフィは, sensitivityは低いがspecificityは高いといえる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Renal cell carcinoma, 67Ga-citrate scan, Ga positive uptake, Prognostic indexes |
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| English |
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| Title | Significance of Ga-67-citrate Tomographic Scan in Renal Cell Carcinoma |
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| Subtitle | |
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| Authors | Juichi KAWAMURA*, Hitoshi ITOH*, Shuichi HIDA*, Osamu YOSHIDA*, Toru FUJITA**, Kanji TORIZUKA** |
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| Authors(kana) | |
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| Organization | *Department of Urology, **Department of Nuclear Medicine, Faculty of Medicine, Kyoto University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 4 |
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| Page | 491-499 |
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| Year/Month | 1985/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Although an application of the Ga-67 citrate scan to renal cell carcinoma is limited because of the relatively poor gallium uptake by the primary renal tumors, remarkable Ga uptake has been noted in some cases of patients with renal cell carcinoma. This study clarifies the characteristics of Ga uptake by the diseased kidney in relation to the tumor stage and grade, clinical laboratory data and prognosis. A frontal tomographic whole body scan using Ga-67 citrate was performed on 56 patients with renal cell carcinoma successively confirmed by operation and autopsy. Positive Ga uptake by the kidney in 28 patients (50%) correlated well to the clinicopathologically higher grade and stage of the tumor and with abnormal values in prognostic indexes in the blood such as erythrocyte sedimentation rate, CRP, α2 globulin, ferritin and copper. Gallium uptake by the pulmonary metastatic lesions was found in 11 out of 17 cases and all cases with positive uptake by the pulmonary metastatic lesions belonged to the Ga positive group. During the follow-up period of 2 to 60 months, 10 patients are alive (7 without tumor, 3 with tumor) and 18 died in the Ga positive group, while in the Ga negative/equivocal groups during the follow-up period of 3 to 41 months, 4 patients died and 24 are alive (20 without tumor, 4 with tumor) . Average 3-year survival rate was 21.0% in the Ga positive group, while 78.8%in the Ga negative/equivocal groups. Thus, since the sensitivity of Ga-67 scan is low but the specificity is high, the positive Ga uptake is indicative of an ominous clinical course and shorter survival in patients with renal cell carcinoma. |
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| Practice | Clinical medicine |
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| Keywords | Renal cell carcinoma, 67Ga-citrate scan, Ga positive uptake, Prognostic indexes |
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